FOSB and FAM222B

Data Source:
BioGRID (two hybrid)

		FOSB	FAM222B
Description		FosB proto-oncogene, AP-1 transcription factor subunit	family with sequence similarity 222 member B
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Intracellular Membrane-bounded Organelle	Nucleoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Female Pregnancy Response To Mechanical Stimulus Response To Progesterone Cellular Response To Hormone Stimulus Response To Drug Response To Morphine Positive Regulation Of Transcription By RNA Polymerase II Response To Corticosterone Response To CAMP Cellular Response To Calcium Ion
Pathways		Estrogen-dependent gene expression NGF-stimulated transcription NGF-stimulated transcription
Drugs
Diseases
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Heel bone mineral density ( 30598549 28869591)	Estimated glomerular filtration rate reduction (30%) ( 30955190) Hemoglobin ( 32888494) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494 27863252) Mean corpuscular volume ( 29403010 32888494 27863252) Red blood cell count ( 32888494) Red cell distribution width ( 27863252)
Interacting Genes		28 interacting genes: AGXT ATF2 CENPO CREB5 CYTH4 DNMT3L ENKD1 EP300 FAM222B FAM90A1 FOXP3 GLIS2 JUN JUNB JUND NCK2 NEDD9 PHC2 PHF1 POGZ POU6F2 ROR2 SRA1 TENT5B TLE5 TLX3 VEZF1 ZC3H10	35 interacting genes: ANKRD10 BAG4 BANP BPIFA1 C10orf55 C19orf54 CDCA4 CNFN FAM168B FHL3 FOSB HYI INTS11 KRTAP11-1 KRTAP26-1 KRTAP3-1 LRRC61 OIP5 PDLIM4 PFDN5 PLA2G10 PRR20A PRR20B PRR20C PRR20D PRR20E RUNX1 SOHLH1 TRIP6 TSC1 TTLL12 UBQLN2 UFSP1 WWOX ZMYND12
Entrez ID		2354	55731
HPRD ID		01270	07693
Ensembl ID		ENSG00000125740	ENSG00000173065
Uniprot IDs		A0A024R0P6 K7EKC1 P53539	A0A024QZ60 B3KQ88 B3KTH5 B4DRX9 Q8WU58
PDB IDs		5VPA 5VPB 5VPC 5VPD 5VPE 5VPF 6UCI 6UCL 6UCM
Enriched GO Terms of Interacting Partners?
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