ST8SIA4 and NCAM1

Data Source:
HPRD (in vitro)

		ST8SIA4	NCAM1
Description		ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	neural cell adhesion molecule 1
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GO Annotations	Cellular Component	Golgi Membrane Integral Component Of Membrane	Golgi Membrane Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Anchored Component Of Membrane Neuron Projection Collagen-containing Extracellular Matrix
	Molecular Function	Alpha-N-acetylneuraminate Alpha-2,8-sialyltransferase Activity Sialic Acid Binding	Virus Receptor Activity Protein Binding
	Biological Process	Ganglioside Biosynthetic Process Cellular Protein Modification Process Protein Glycosylation N-glycan Processing Nervous System Development Oligosaccharide Metabolic Process Sialylation	MAPK Cascade Cell Adhesion Axon Guidance Viral Entry Into Host Cell Interferon-gamma-mediated Signaling Pathway Commissural Neuron Axon Guidance Regulation Of Semaphorin-plexin Signaling Pathway
Pathways		Sialic acid metabolism NCAM1 interactions	ECM proteoglycans NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth NCAM1 interactions NCAM1 interactions Signal transduction by L1 RAF/MAP kinase cascade Interferon gamma signaling
Drugs
Diseases
GWAS		Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Response to radiotherapy in cancer (late toxicity) ( 24785509) Systemic lupus erythematosus ( 29848360 28714469) Waist circumference adjusted for body mass index ( 28552196) White blood cell count ( 32888494)	Age at first sexual intercourse ( 27089180) Blood protein levels ( 30072576 29875488) Body mass index ( 25673413) Cannabis use ( 30150663 27023175) Cardiac muscle measurement ( 21212386) Coffee consumption ( 31046077) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Entorhinal cortical thickness ( 21116278) Experiencing mood swings ( 29500382) Feeling miserable ( 29500382) Feeling tense ( 29500382) General factor of neuroticism ( 30867560) Gut microbiota (bacterial taxa) ( 27694959) Heel bone mineral density ( 30598549 28869591) Macular thickness ( 30535121) Mood instability ( 31168069) Neurociticism ( 29500382) Number of sexual partners ( 30643258) Pulse pressure ( 27841878) Risk-taking tendency (4-domain principal component model) ( 30643258) Sense of smell ( 26632684) Smoking initiation ( 30617275) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Smoking status (heavy vs never) ( 26423011) Suicide attempts in depression or bipolar disorder ( 24964207) Systolic blood pressure ( 27841878)
Interacting Genes		1 interacting genes: NCAM1	19 interacting genes: ATXN1 BDNF EGFR FGFR1 FYN GDNF GFRA1 L1CAM NCAN PLCG1 PPP1CA PRNP RHEB SPTB ST8SIA2 ST8SIA3 ST8SIA4 TUBB UCHL1
Entrez ID		7903	4684
HPRD ID		03970	00301
Ensembl ID		ENSG00000113532	ENSG00000149294
Uniprot IDs		Q92187	A0A087WWD4 P13591
PDB IDs		5Y22 5Y3U 6AHZ	2E3V 2HAZ 2VKW 2VKX 3MTR 5AEA 5LKN
Enriched GO Terms of Interacting Partners?
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