Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
HTR2C and SLC29A1
Data Source:
BioGRID
(two hybrid)
HTR2C
SLC29A1
Description
5-hydroxytryptamine receptor 2C
solute carrier family 29 member 1 (Augustine blood group)
Image
GO Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Dendrite
Synapse
G Protein-coupled Serotonin Receptor Complex
Plasma Membrane
Integral Component Of Plasma Membrane
Membrane
Integral Component Of Membrane
Basolateral Plasma Membrane
Apical Plasma Membrane
Presynapse
Postsynapse
Molecular Function
Gq/11-coupled Serotonin Receptor Activity
G Protein-coupled Serotonin Receptor Activity
Protein Binding
Neurotransmitter Receptor Activity
Identical Protein Binding
Serotonin Binding
1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding
Neurotransmitter Transmembrane Transporter Activity
Nucleoside Transmembrane Transporter Activity
Purine Nucleoside Transmembrane Transporter Activity
Uridine Transmembrane Transporter Activity
Biological Process
Behavioral Fear Response
Cellular Calcium Ion Homeostasis
G Protein-coupled Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Phospholipase C-activating Serotonin Receptor Signaling Pathway
Chemical Synaptic Transmission
Locomotory Behavior
Feeding Behavior
Positive Regulation Of Phosphatidylinositol Biosynthetic Process
CGMP-mediated Signaling
Regulation Of Nervous System Process
Regulation Of Appetite
Response To Drug
Regulation Of Corticotropin-releasing Hormone Secretion
Positive Regulation Of Fat Cell Differentiation
Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway
Positive Regulation Of ERK1 And ERK2 Cascade
G Protein-coupled Serotonin Receptor Signaling Pathway
Neurotransmitter Uptake
Nucleobase-containing Compound Metabolic Process
Neurotransmitter Transport
Lactation
Nucleoside Transport
Purine Nucleoside Transmembrane Transport
Uridine Transport
Sleep
Adenosine Transport
Excitatory Postsynaptic Potential
Cellular Response To Glucose Stimulus
Cellular Response To Hypoxia
Pyrimidine-containing Compound Transmembrane Transport
Neurotransmitter Reuptake
Transport Across Blood-brain Barrier
Nucleoside Transmembrane Transport
Pathways
Serotonin receptors
G alpha (q) signalling events
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
Drugs
Tramadol
Ziprasidone
Methysergide
Cabergoline
Amitriptyline
Olanzapine
Clozapine
Mirtazapine
Loxapine
Promazine
Cyproheptadine
Imipramine
Fluoxetine
Chlorpromazine
Chlorpromazine
Haloperidol
Nortriptyline
Amoxapine
Fenfluramine
Lisuride
Fluphenazine
Trazodone
Ergotamine
Apomorphine
Paroxetine
Trimipramine
Risperidone
Propiomazine
Minaprine
Cyclobenzaprine
Maprotiline
Ergoloid mesylate
Tegaserod
Doxepin
Nefazodone
Desipramine
Escitalopram
Pergolide
Dexfenfluramine
Bromocriptine
Ketamine
Quetiapine
Aripiprazole
Chlorprothixene
Clomipramine
Paliperidone
Yohimbine
Methotrimeprazine
Midomafetamine
4-Bromo-2,5-dimethoxyphenethylamine
Lorcaserin
Dapoxetine
Lofexidine
Epicept NP-1
Sertindole
Mianserin
Pizotifen
Asenapine
Ocaperidone
Dotarizine
Deramciclane
Agomelatine
Esmirtazapine
Captodiame
Etoperidone
Lorpiprazole
Setiptiline
Dihydroergocornine
m-Chlorophenylpiperazine
Gilteritinib
Sarpogrelate
Eplivanserin
Tiapride
Dihydroergocristine
2,5-Dimethoxy-4-ethylthioamphetamine
Aripiprazole lauroxil
Troglitazone
Ethanol
Fostamatinib
Diseases
GWAS
Heel bone mineral density (
30598549
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
27863252
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Red cell distribution width (
32888494
)
Waist-to-hip ratio adjusted for BMI (
26426971
)
Waist-to-hip ratio adjusted for BMI (age <50) (
26426971
)
Waist-to-hip ratio adjusted for BMI (age >50) (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
34 interacting genes:
APBA1
ARRB2
ATP2B3
ATP6AP2
ATP6V0C
C4orf3
CALM1
CBX3
CNIH1
CRELD1
DLG4
EMP1
ERG28
GHITM
GJA1
GNAQ
GPR37
GPRC5B
LIN7C
MFSD14A
MPDZ
PLP1
RTN4
SGCB
SLC29A1
SLC39A1
SLC39A9
SNTA1
SPNS1
TM9SF2
TMBIM6
TMEM147
TMEM94
TPI1
3 interacting genes:
CREB3
HTR2C
STK19
Entrez ID
3358
2030
HPRD ID
02429
03724
Ensembl ID
ENSG00000147246
ENSG00000112759
Uniprot IDs
K9J958
P28335
Q99808
PDB IDs
6BQG
6BQH
6OB6
6OB7
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?