BTG2 and CNOT7

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		BTG2	CNOT7
Description		BTG anti-proliferation factor 2	CCR4-NOT transcription complex subunit 7
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Extracellular Exosome	P-body Nucleus Cytoplasm Cytosol Membrane Nuclear Body Nuclear Speck CCR4-NOT Complex CCR4-NOT Core Complex
	Molecular Function	Transcription Corepressor Activity Protein Binding	3'-5'-exoribonuclease Activity Transcription Corepressor Activity RNA Binding Exoribonuclease Activity Poly(A)-specific Ribonuclease Activity Protein Binding Transcription Factor Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Protein Methylation Cellular Response To DNA Damage Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Negative Regulation Of Cell Population Proliferation Associative Learning Response To Mechanical Stimulus Anterior/posterior Pattern Specification Response To Organic Cyclic Compound Negative Regulation Of Translation Dentate Gyrus Development Central Nervous System Neuron Development Neuron Projection Development Skeletal Muscle Cell Differentiation Response To Peptide Hormone Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Mitotic Cell Cycle Response To Electrical Stimulus Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Neural Precursor Cell Proliferation	Nuclear-transcribed MRNA Poly(A) Tail Shortening Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Gene Expression Negative Regulation Of Translation Gene Silencing By RNA P-body Assembly Gene Silencing By MiRNA Regulation Of Tyrosine Phosphorylation Of STAT Protein Exonucleolytic Catabolism Of Deadenylated MRNA Positive Regulation Of Viral Genome Replication Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Pathways		TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Drugs
Diseases
GWAS		Immature fraction of reticulocytes ( 32888494 27863252) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494 27863252) Red cell distribution width ( 32888494 27863252 28957414)
Interacting Genes		11 interacting genes: CNOT7 CNOT8 HOXB9 HOXC8 PICK1 PRKCA PRMT1 SKP2 SMAD1 SMAD9 SRA1	28 interacting genes: APP BTG1 BTG2 BTG3 CDK1 CDK2 CDK4 CDK6 CNOT6 FBXO7 FHL3 FOXC2 HOXD4 IKBKG LSM3 MRFAP1L1 NMI PABPC1 PIAS1 PSMC1 PSMC2 SCARA3 SH3GLB2 TCP11L1 TEX11 TOB1 TOB2 TSG101
Entrez ID		7832	29883
HPRD ID		03357	05370
Ensembl ID		ENSG00000159388	ENSG00000198791
Uniprot IDs		P78543	Q96IQ6 Q9UIV1
PDB IDs		3DJU 3E9V	2D5R 4GMJ
Enriched GO Terms of Interacting Partners?
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