CNOT7 and TCP11L1

Data Source:
BioGRID (two hybrid)

		CNOT7	TCP11L1
Description		CCR4-NOT transcription complex subunit 7	t-complex 11 like 1
Image			No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Membrane Nuclear Body Nuclear Speck CCR4-NOT Complex CCR4-NOT Core Complex	Microtubule
	Molecular Function	3'-5'-exoribonuclease Activity Transcription Corepressor Activity RNA Binding Exoribonuclease Activity Poly(A)-specific Ribonuclease Activity Protein Binding Transcription Factor Binding Metal Ion Binding	Protein Binding
	Biological Process	Nuclear-transcribed MRNA Poly(A) Tail Shortening Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Gene Expression Negative Regulation Of Translation Gene Silencing By RNA P-body Assembly Gene Silencing By MiRNA Regulation Of Tyrosine Phosphorylation Of STAT Protein Exonucleolytic Catabolism Of Deadenylated MRNA Positive Regulation Of Viral Genome Replication Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay	Signal Transduction
Pathways		Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Drugs
Diseases
GWAS			Anger ( 24489884) Platelet distribution width ( 32888494)
Interacting Genes		28 interacting genes: APP BTG1 BTG2 BTG3 CDK1 CDK2 CDK4 CDK6 CNOT6 FBXO7 FHL3 FOXC2 HOXD4 IKBKG LSM3 MRFAP1L1 NMI PABPC1 PIAS1 PSMC1 PSMC2 SCARA3 SH3GLB2 TCP11L1 TEX11 TOB1 TOB2 TSG101	23 interacting genes: APP CNOT7 DDIT4L ERCC6L2 HMG20A IKBKG IPO4 LHX2 MAGEA12 MEOX1 NEDD4 PAX6 PLEKHS1 PRXL2B PSMD4 REL SDCBP2 SNW1 TBX6 TRIM21 TSNAX VPS52 WWTR1
Entrez ID		29883	55346
HPRD ID		05370	07750
Ensembl ID		ENSG00000198791	ENSG00000176148
Uniprot IDs		Q96IQ6 Q9UIV1	B3KQZ4 Q9NUJ3
PDB IDs		2D5R 4GMJ
Enriched GO Terms of Interacting Partners?
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