CSDE1 and WNK1

Data Source:
BioGRID (two hybrid)

		CSDE1	WNK1
Description		cold shock domain containing E1	WNK lysine deficient protein kinase 1
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GO Annotations	Cellular Component	P-body Golgi Apparatus Cytosol Plasma Membrane Cytoplasmic Stress Granule CRD-mediated MRNA Stability Complex	Cytoplasm Cytosol Membrane
	Molecular Function	RNA Binding Protein Binding RNA Stem-loop Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Chloride Channel Inhibitor Activity Potassium Channel Inhibitor Activity Protein Kinase Binding Phosphatase Binding Protein Kinase Activator Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Regulation Of Translational Initiation Male Gonad Development Stress Granule Assembly Nuclear-transcribed MRNA Catabolic Process, No-go Decay IRES-dependent Viral Translational Initiation	Regulation Of Sodium Ion Transport Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Ion Transport Signal Transduction Negative Regulation Of Sodium Ion Transport Positive Regulation Of T Cell Chemotaxis Negative Regulation Of Phosphatase Activity Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Activation Of Protein Kinase Activity Negative Regulation Of Cell-cell Adhesion Mediated By Integrin Negative Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of GTPase Activity Intracellular Signal Transduction Chemokine (C-C Motif) Ligand 21 Signaling Pathway Neuron Development Regulation Of Cellular Process Ion Homeostasis T Cell Receptor Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Lymphocyte Migration Into Lymph Node Negative Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Potassium Ion Import Across Plasma Membrane Regulation Of Cation Transmembrane Transport Cellular Response To Chemokine Positive Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways			Stimuli-sensing channels
Drugs
Diseases			Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)
GWAS		Autism ( 24189344)	Adult body size ( 32376654) Blood protein levels ( 29875488) Body mass index ( 25673413 29273807) Body size at age 10 ( 32376654) Eosinophil counts ( 27863252) Eosinophil percentage of white cells ( 27863252) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Manganese levels ( 26025379) Monocyte percentage of white cells ( 32888494) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Squamous cell lung carcinoma ( 28604730) Stroke ( 19369658)
Interacting Genes		10 interacting genes: C11orf68 ERBB2 FAM9B HID1 HNRNPD PABPC1 PCSK7 STT3A SYNCRIP WNK1	36 interacting genes: ADRB2 AKT1 ARAF ATXN1 BAG3 CLTC COPS5 CSDE1 E2F3 FHL3 FLNC GLIS2 KLHL2 KLHL3 MAP2K1 MAP3K2 MAP3K3 MT-ATP8 PFKP PRKAR1A PRKAR1B PVR RANBP9 SLC9A1 SYT2 TNRC6A TSC22D1 TULP3 UBE2I UPF2 WNK2 YWHAE YWHAG YWHAZ ZNF106 ZYX
Entrez ID		7812	65125
HPRD ID		15949	05570
Ensembl ID		ENSG00000009307	ENSG00000060237
Uniprot IDs		A0A024R0E2 A0A024R0K2 O75534	A5D8Z4 F5GWT4 Q9H4A3
PDB IDs		1WFQ 1X65 2YTV 2YTX 2YTY	4PWN 5TF9 5WDY 5WE8 6FBK
Enriched GO Terms of Interacting Partners?
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