MAP2K4 and TRIB1

Data Source:
HPRD (in vivo)

		MAP2K4	TRIB1
Description		mitogen-activated protein kinase kinase 4	tribbles pseudokinase 1
Image
GO Annotations	Cellular Component	Nucleus Cytosol Axon Dendrite Cytoplasm Perikaryon	Nucleus Cytoplasm
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding JUN Kinase Kinase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding	Protein Kinase Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Transcription Factor Binding Mitogen-activated Protein Kinase Kinase Binding Ubiquitin Protein Ligase Binding Ubiquitin-protein Transferase Regulator Activity
	Biological Process	Activation Of MAPK Activity Apoptotic Process Signal Transduction JNK Cascade Activation Of JUN Kinase Activity Response To Wounding Peptidyl-tyrosine Phosphorylation Positive Regulation Of Smooth Muscle Cell Apoptotic Process Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of DNA Replication Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Mechanical Stimulus Cellular Response To Sorbitol Negative Regulation Of Motor Neuron Apoptotic Process	Protein Phosphorylation Negative Regulation Of Protein Kinase Activity JNK Cascade Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Lipopolysaccharide Regulation Of MAP Kinase Activity Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Eosinophil Differentiation Positive Regulation Of Macrophage Differentiation Negative Regulation Of Neutrophil Differentiation Negative Regulation Of Smooth Muscle Cell Proliferation
Pathways		Oxidative Stress Induced Senescence Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Uptake and function of anthrax toxins MAP3K8 (TPL2)-dependent MAPK1/3 activation	NGF-stimulated transcription
Drugs
Diseases
GWAS		Asthma ( 32296059) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Response to amphetamines ( 22952603)	Adiponectin levels ( 22479202) Adult body size ( 32376654) Alanine transaminase levels ( 29403010) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Birth weight ( 31043758 27680694) C-reactive protein levels ( 30388399) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) Carotid intima media thickness x smoking interaction ( 32117412) Cholesterol ( 31902109) Cholesterol, total ( 24097068 19060911 25961943 20686565 26582766) Coronary artery disease ( 32469254 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 27841878) Estimated glomerular filtration rate ( 31152163 31015462 30604766) Fractures (paediatric) ( 32742401) Gamma glutamyl transferase levels ( 29403010) Glycine levels ( 31070104 30837465) HDL cholesterol ( 24097068 25961943 20686565) HDL Cholesterol - Triglycerides (HDLC-TG) ( 21386085) HDL cholesterol levels ( 32203549 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hypertriglyceridemia ( 27599772) Inflammatory bowel disease ( 23128233) LDL cholesterol ( 24097068 20864672 19060911 25961943 20686565) LDL cholesterol levels ( 32203549 28334899 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lipid metabolism phenotypes ( 19936222) Lipid traits ( 24386095) Liver enzyme levels (alanine transaminase) ( 22001757) Liver enzyme levels (alkaline phosphatase) ( 22001757) Low density lipoprotein cholesterol levels ( 29403010) Metabolic syndrome ( 31589552) Metabolite levels ( 23823483) Metabolite levels (lipoprotein measures) ( 27005778) Microalbuminuria ( 31511532) Mosquito bite size ( 28199695) Myocardial infarction ( 26343387) Nonalcoholic fatty liver disease ( 31311600) Obesity-related traits ( 23251661) Response to statin therapy ( 20339536) Rosacea symptom severity ( 29771307) Serum alkaline phosphatase levels ( 29403010) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Serum total protein level ( 29403010) Systolic blood pressure ( 27841878) Total cholesterol levels ( 28334899 29403010) Triglyceride levels ( 32203549 28334899 31647587 30911093 29403010 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 24097068 18193043 18193044 20864672 19060906 24886709 20139978 25961943 26780889 20686565 26582766) Triglycerides-Blood Pressure (TG-BP) ( 21386085) Type 2 diabetes ( 32499647) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 30910378 31511532) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) White blood cell count (basophil) ( 29403010)
Interacting Genes		43 interacting genes: AKT1 ALDOB APP ARRB1 ARRB2 CFLAR CYLC2 DUSP22 EFNA4 FBP2 FLNA FLNC GEMIN5 ITCH JUN LRRK2 MAP2K6 MAP3K1 MAP3K10 MAP3K11 MAP3K12 MAP3K14 MAP3K2 MAP3K20 MAP3K3 MAP3K4 MAP3K5 MAP3K7 MAP3K8 MAP4K2 MAPK1 MAPK10 MAPK12 MAPK14 MAPK8 MAPK8IP3 MAPK9 NBR1 RBBP8 SPAG9 STX17 TRIB1 UBC	8 interacting genes: ALOX12 CEBPB CEBPD CEBPE COP1 MAP2K1 MAP2K4 MAP2K7
Entrez ID		6416	10221
HPRD ID		03213	09863
Ensembl ID		ENSG00000065559	ENSG00000173334
Uniprot IDs		P45985	Q96RU8
PDB IDs		3ALN 3ALO 3VUT	5CEK 5CEM 5IGO 5IGQ 6DC0
Enriched GO Terms of Interacting Partners?
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