ZP3 and ACR

Data Source:
HPRD (in vitro)

		ZP3	ACR
Description		zona pellucida glycoprotein 3	acrosin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Membrane Extracellular Matrix Egg Coat Collagen-containing Extracellular Matrix	Extracellular Region Nucleus Golgi-associated Vesicle Protein-containing Complex Acrosomal Matrix
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Carbohydrate Binding Acrosin Binding Structural Constituent Of Egg Coat Identical Protein Binding Receptor Ligand Activity	Protease Binding DNA Binding Amidase Activity Serine-type Endopeptidase Activity Copper Ion Binding Protein Binding Mannose Binding Serine-type Peptidase Activity Zinc Ion Binding Fucose Binding
	Biological Process	Positive Regulation Of Type IV Hypersensitivity Blastocyst Formation Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Leukocyte Migration Positive Regulation Of Humoral Immune Response Binding Of Sperm To Zona Pellucida Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-4 Production Egg Coat Formation Positive Regulation Of T Cell Proliferation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Phosphatidylinositol-mediated Signaling Oocyte Development Positive Regulation Of Inflammatory Response Positive Regulation Of Acrosome Reaction Negative Regulation Of Binding Of Sperm To Zona Pellucida Positive Regulation Of Acrosomal Vesicle Exocytosis Positive Regulation Of Ovarian Follicle Development Positive Regulation Of Antral Ovarian Follicle Growth	Acrosome Matrix Dispersal Activation Of Adenylate Cyclase Activity Single Fertilization Binding Of Sperm To Zona Pellucida Acrosome Reaction Penetration Of Zona Pellucida Response To Steroid Hormone
Pathways		Interaction With Cumulus Cells And The Zona Pellucida	Acrosome Reaction and Sperm:Oocyte Membrane Binding
Drugs
Diseases
GWAS		Parkinson disease and lewy body pathology ( 25663231)
Interacting Genes		11 interacting genes: ACR CLDN11 ENGASE FURIN MALL MICALL1 MRPS16 OR2L13 PCDH17 SPACA3 UBAP2L	3 interacting genes: SERPINA5 ZP2 ZP3
Entrez ID		7784	49
HPRD ID		01690	06342
Ensembl ID		ENSG00000188372	ENSG00000100312
Uniprot IDs		P21754	P10323
PDB IDs
Enriched GO Terms of Interacting Partners?
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