ZNF131 and PIP4K2B

Data Source:
BioGRID (two hybrid)

		ZNF131	PIP4K2B
Description		zinc finger protein 131	phosphatidylinositol-5-phosphate 4-kinase type 2 beta
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Intermediate Filament Cytoskeleton	Nucleus Nucleoplasm Autophagosome Endoplasmic Reticulum Membrane Cytosol Plasma Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Metal Ion Binding	Protein Binding ATP Binding GTP Binding 1-phosphatidylinositol-4-phosphate 5-kinase Activity 1-phosphatidylinositol-5-phosphate 4-kinase Activity Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Cell Surface Receptor Signaling Pathway Regulation Of Autophagy Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol Phosphorylation Autophagosome-lysosome Fusion Negative Regulation Of 1-phosphatidylinositol-4-phosphate 5-kinase Activity 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Biosynthetic Process Positive Regulation Of Autophagosome Assembly
Pathways		SUMOylation of transcription cofactors	Synthesis of PIPs at the plasma membrane PI5P Regulates TP53 Acetylation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Synthesis of PIPs in the nucleus
Drugs			Fostamatinib
Diseases
GWAS		Body mass index ( 25673413) Mean corpuscular hemoglobin concentration ( 32888494) Menarche (age at onset) ( 25231870)	Height ( 28552196 20881960 31562340)
Interacting Genes		9 interacting genes: EMSY FHL2 FHL5 HSPB1 KPNA2 KPNA3 KPNA6 MORN4 PIP4K2B	17 interacting genes: BTK CDCA7L CLK1 CSNK2A1 HMBOX1 HSPB7 INO80B KYNU MLH1 PRPF3 PSMB1 RPRD1B TNFRSF1A TRIM55 TRIM63 UBQLN4 ZNF131
Entrez ID		7690	8396
HPRD ID		07239	04463
Ensembl ID		ENSG00000172262	ENSG00000276293
Uniprot IDs		A0A024R087 P52739	P78356
PDB IDs			1BO1 3WZZ 3X01 3X02 3X03 3X04 3X05 3X06 3X07 3X08 3X09 3X0A 3X0B 3X0C 6K4G 6K4H
Enriched GO Terms of Interacting Partners?
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