SF1 and GAS7

Data Source:
BioGRID (pull down)

		SF1	GAS7
Description		splicing factor 1	growth arrest specific 7
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Ribosome	Cytoplasm Cytoskeleton Actin Filament Plasma Membrane
	Molecular Function	Transcription Corepressor Activity RNA Binding MRNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Pre-mRNA Branch Point Binding	Protein Binding Actin Filament Binding
	Biological Process	Spliceosomal Complex Assembly MRNA 3'-splice Site Recognition MRNA Splicing, Via Spliceosome Negative Regulation Of Transcription, DNA-templated Regulation Of MRNA Splicing, Via Spliceosome	Actin Filament Polymerization Neuron Projection Morphogenesis
Pathways		mRNA Splicing - Major Pathway
Drugs		Artenimol
Diseases
GWAS		Mean reticulocyte volume ( 32888494) Urate levels ( 21768215)	Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Glaucoma ( 30104761 31959993 30054594) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 29891935) Gut microbiota relative abundance (Prevotella) ( 33208821) Heel bone mineral density ( 30598549) Intraocular pressure ( 29617998 25173106 24002674 22570627 31798171 29785010 31959993 30054594 28073927 29235454) Medication use (antiglaucoma preparations and miotics) ( 31015401) Proteinuria and chronic kidney disease ( 26420894)
Interacting Genes		58 interacting genes: APBB1 ATXN1 BCAS2 BCL2 CDC42 CIAO1 DDX17 DUX4L9 EWSR1 FAM168A FUS GAS7 HNRNPF HNRNPH1 HNRNPH2 HNRNPK HNRNPUL1 IL7R ILF3 ITCH KRTAP26-1 MIR106B MIR155 MIR19B2 MIR34A MIRLET7G MKRN3 NCK2 NFKB1 OSTF1 PLSCR1 PRKG1 PRPF40A PSMA3 PUF60 RBM10 RBM17 RBM4 RBM7 RBPMS SEC23A SF3A1 SF3B1 SF3B4 TAF15 TCERG1 TNPO2 TRIM23 TRIM69 TTN TXNL4B U2AF2 UBL5 WBP4 WDR77 WDR83 WWP2 ZNF461	26 interacting genes: ABI1 ACTA1 APBB1IP ATXN1L CDC37 CREB3L2 CYFIP1 CYFIP2 DIAPH1 FMNL1 GAPDH KHDRBS1 LSM4 MCRS1 MYBPC2 NCKAP1 NCKAP1L NCKIPSD NTAQ1 PACSIN1 RPLP0 SF1 SF3A1 SFPQ WASF2 YIF1A
Entrez ID		7536	8522
HPRD ID		03306	16011
Ensembl ID		ENSG00000168066	ENSG00000007237
Uniprot IDs		A0A024R566 A0A024R572 A0A024R588 A0A024R5D9 B4DX42 Q15637	O60861
PDB IDs		1K1G 1O0P 1OPI 2M09 2M0G 4FXW 4FXX	2LX7 2YSH
Enriched GO Terms of Interacting Partners?
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