GAS7 and NCKAP1L

Data Source:
BioGRID (pull down)

		GAS7	NCKAP1L
Description		growth arrest specific 7	NCK associated protein 1 like
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Actin Filament Plasma Membrane	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Membrane Secretory Granule Membrane SCAR Complex Extracellular Exosome Ficolin-1-rich Granule Membrane
	Molecular Function	Protein Binding Actin Filament Binding	GTPase Activator Activity Protein Binding Protein Kinase Activator Activity Protein-containing Complex Binding
	Biological Process	Actin Filament Polymerization Neuron Projection Morphogenesis	Cell Morphogenesis B Cell Homeostasis Myeloid Cell Homeostasis Chemotaxis Cell Migration Maintenance Of Cell Polarity Cell Projection Assembly Neutrophil Chemotaxis Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Positive Regulation Of B Cell Proliferation Activation Of Protein Kinase Activity Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-6 Production Positive Regulation Of Cell Adhesion Mediated By Integrin Erythrocyte Homeostasis Negative Regulation Of Myosin-light-chain-phosphatase Activity Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of T Cell Proliferation Positive Regulation Of Phosphorylation Response To Drug T Cell Homeostasis Negative Regulation Of Apoptotic Process Neutrophil Degranulation Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Positive Regulation Of GTPase Activity Positive Regulation Of B Cell Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Erythrocyte Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Neuron Projection Morphogenesis Erythrocyte Development B Cell Receptor Signaling Pathway Positive Regulation Of Phagocytosis, Engulfment Protein-containing Complex Assembly Actin Polymerization-dependent Cell Motility Positive Regulation Of Neutrophil Chemotaxis
Pathways			Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Neutrophil degranulation FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Glaucoma ( 30104761 31959993 30054594) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 29891935) Gut microbiota relative abundance (Prevotella) ( 33208821) Heel bone mineral density ( 30598549) Intraocular pressure ( 29617998 25173106 24002674 22570627 31798171 29785010 31959993 30054594 28073927 29235454) Medication use (antiglaucoma preparations and miotics) ( 31015401) Proteinuria and chronic kidney disease ( 26420894)	Hip circumference adjusted for BMI ( 28552196) Obesity-related traits ( 23251661)
Interacting Genes		26 interacting genes: ABI1 ACTA1 APBB1IP ATXN1L CDC37 CREB3L2 CYFIP1 CYFIP2 DIAPH1 FMNL1 GAPDH KHDRBS1 LSM4 MCRS1 MYBPC2 NCKAP1 NCKAP1L NCKIPSD NTAQ1 PACSIN1 RPLP0 SF1 SF3A1 SFPQ WASF2 YIF1A	2 interacting genes: GAS7 PRPF40A
Entrez ID		8522	3071
HPRD ID		16011	00781
Ensembl ID		ENSG00000007237	ENSG00000123338
Uniprot IDs		O60861	P55160
PDB IDs		2LX7 2YSH
Enriched GO Terms of Interacting Partners?
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