XPC and DDB2

Data Source:
BioGRID (affinity chromatography technology, imaging technique)
HPRD (in vivo)

		XPC	DDB2
Description		XPC complex subunit, DNA damage recognition and repair factor	damage specific DNA binding protein 2
Image
GO Annotations	Cellular Component	Nucleotide-excision Repair Complex Nucleotide-excision Repair Factor 2 Complex Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytosol Plasma Membrane Intracellular Membrane-bounded Organelle XPC Complex Site Of DNA Damage	Nucleus Nucleoplasm Cell Junction Cul4B-RING E3 Ubiquitin Ligase Complex Protein-containing Complex Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Heteroduplex DNA Loop Binding Bubble DNA Binding Damaged DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity Protein Binding Protein-containing Complex Binding	DNA Binding Damaged DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Protein-containing Complex Binding
	Biological Process	Nucleotide-excision Repair, DNA Damage Recognition Nucleotide-excision Repair, DNA Duplex Unwinding Pyrimidine Dimer Repair By Nucleotide-excision Repair DNA Repair Nucleotide-excision Repair Nucleotide-excision Repair, Preincision Complex Assembly Mismatch Repair Response To UV-B Response To Auditory Stimulus Intra-S DNA Damage Checkpoint Response To Drug Positive Regulation Of Transcription, DNA-templated Global Genome Nucleotide-excision Repair UV-damage Excision Repair Regulation Of Mitotic Cell Cycle Phase Transition UV-damage Excision Repair, DNA Incision	Protein Polyubiquitination Nucleotide-excision Repair, DNA Damage Recognition Nucleotide-excision Repair, DNA Duplex Unwinding DNA Repair Nucleotide-excision Repair Pyrimidine Dimer Repair Nucleotide-excision Repair, Preincision Complex Stabilization Nucleotide-excision Repair, Preincision Complex Assembly Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Response To UV Protein Deubiquitination Nucleotide-excision Repair, DNA Incision Histone H2A Monoubiquitination Post-translational Protein Modification Protein Autoubiquitination Global Genome Nucleotide-excision Repair UV-damage Excision Repair
Pathways		SUMOylation of DNA damage response and repair proteins DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER	Ub-specific processing proteases DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER TP53 Regulates Transcription of DNA Repair Genes Neddylation
Drugs
Diseases		Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome	Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS			Acne (severe) ( 24399259) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Feeling lonely ( 29500382) Feeling miserable ( 29500382) Lymphocyte percentage of white cells ( 32888494) Monocyte percentage of white cells ( 32888494) Neurociticism ( 29500382) Neuroticism ( 29255261) Refractive error ( 32231278) Triglyceride levels ( 32203549)
Interacting Genes		15 interacting genes: CETN2 DDB2 ERCC3 GTF2H1 LSM3 MDM2 PSMD4 RAD23A RAD23B RPA1 SMAD1 TDG USP7 XPA ZNF512B	19 interacting genes: ABL1 AR CUL4A CUL4B DCLRE1C DDB1 E2F1 H2AC20 H3C14 HDAC1 NR5A2 NTMT1 PAQR3 RAD51 TOP1 USP24 USP40 XPA XPC
Entrez ID		7508	1643
HPRD ID		02046	02886
Ensembl ID		ENSG00000154767	ENSG00000134574
Uniprot IDs		Q01831 X5DRB1	Q92466
PDB IDs		2A4J 2GGM 2OBH 2RVB	3EI4 3I7L 4E54 4E5Z 6R8Y 6R8Z 6R90 6R91 6R92
Enriched GO Terms of Interacting Partners?
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