XPC and LSM3

Data Source:
HPRD (two hybrid)

		XPC	LSM3
Description		XPC complex subunit, DNA damage recognition and repair factor	LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
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GO Annotations	Cellular Component	Nucleotide-excision Repair Complex Nucleotide-excision Repair Factor 2 Complex Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytosol Plasma Membrane Intracellular Membrane-bounded Organelle XPC Complex Site Of DNA Damage	P-body Nucleus Nucleoplasm U6 SnRNP Cytosol U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome Catalytic Step 2 Spliceosome Lsm2-8 Complex Lsm1-7-Pat1 Complex
	Molecular Function	Heteroduplex DNA Loop Binding Bubble DNA Binding Damaged DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity Protein Binding Protein-containing Complex Binding	RNA Binding Protein Binding U6 SnRNA 3'-end Binding
	Biological Process	Nucleotide-excision Repair, DNA Damage Recognition Nucleotide-excision Repair, DNA Duplex Unwinding Pyrimidine Dimer Repair By Nucleotide-excision Repair DNA Repair Nucleotide-excision Repair Nucleotide-excision Repair, Preincision Complex Assembly Mismatch Repair Response To UV-B Response To Auditory Stimulus Intra-S DNA Damage Checkpoint Response To Drug Positive Regulation Of Transcription, DNA-templated Global Genome Nucleotide-excision Repair UV-damage Excision Repair Regulation Of Mitotic Cell Cycle Phase Transition UV-damage Excision Repair, DNA Incision	MRNA Splicing, Via Spliceosome MRNA Processing P-body Assembly Exonucleolytic Catabolism Of Deadenylated MRNA
Pathways		SUMOylation of DNA damage response and repair proteins DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER	mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway
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Diseases		Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS			Chronotype ( 30696823) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 31562340) Offspring birth weight ( 31043758) PR interval ( 32439900) Red blood cell count ( 32888494)
Interacting Genes		15 interacting genes: CETN2 DDB2 ERCC3 GTF2H1 LSM3 MDM2 PSMD4 RAD23A RAD23B RPA1 SMAD1 TDG USP7 XPA ZNF512B	48 interacting genes: CCND3 CDKN2D CEP95 CLNS1A CNOT7 DDIT4L DLX4 EEF1A1 EIF4EBP2 EXOSC1 EXOSC5 GDF9 GSTA1 HSPB1 INCA1 KEAP1 KLF3 LSM1 LSM10 LSM12 LSM2 LSM5 LSM6 LSM7 LSM8 NACC1 PIAS1 QKI SF3B2 SH3GLB2 SMN1 SNRPD1 SNRPD3 SNRPE SNRPF SNRPG TCL1A TEPSIN TFIP11 THOC5 TRAPPC2 TRAPPC2B UTP14A WDR77 WDR83 XPC XRN2 YBX1
Entrez ID		7508	27258
HPRD ID		02046	06283
Ensembl ID		ENSG00000154767	ENSG00000170860
Uniprot IDs		Q01831 X5DRB1	P62310
PDB IDs		2A4J 2GGM 2OBH 2RVB	3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9
Enriched GO Terms of Interacting Partners?
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