DDB2 and CUL4B

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		DDB2	CUL4B
Description		damage specific DNA binding protein 2	cullin 4B
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cell Junction Cul4B-RING E3 Ubiquitin Ligase Complex Protein-containing Complex Cul4-RING E3 Ubiquitin Ligase Complex	Nucleoplasm Cytosol SCF Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Extracellular Exosome Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	DNA Binding Damaged DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Protein-containing Complex Binding	Damaged DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Protein Polyubiquitination Nucleotide-excision Repair, DNA Damage Recognition Nucleotide-excision Repair, DNA Duplex Unwinding DNA Repair Nucleotide-excision Repair Pyrimidine Dimer Repair Nucleotide-excision Repair, Preincision Complex Stabilization Nucleotide-excision Repair, Preincision Complex Assembly Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Response To UV Protein Deubiquitination Nucleotide-excision Repair, DNA Incision Histone H2A Monoubiquitination Post-translational Protein Modification Protein Autoubiquitination Global Genome Nucleotide-excision Repair UV-damage Excision Repair	G1/S Transition Of Mitotic Cell Cycle Nucleotide-excision Repair, DNA Damage Recognition Nucleotide-excision Repair, DNA Duplex Unwinding Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair, Preincision Complex Stabilization Nucleotide-excision Repair, Preincision Complex Assembly Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Cellular Response To DNA Damage Stimulus Proteasomal Protein Catabolic Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Nucleotide-excision Repair, DNA Incision Histone H2A Monoubiquitination Ribosome Biogenesis DNA Damage Response, Detection Of DNA Damage Post-translational Protein Modification Global Genome Nucleotide-excision Repair UV-damage Excision Repair
Pathways		Ub-specific processing proteases DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER TP53 Regulates Transcription of DNA Repair Genes Neddylation	Recognition of DNA damage by PCNA-containing replication complex DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation
Drugs
Diseases		Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome	Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS		Acne (severe) ( 24399259) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Feeling lonely ( 29500382) Feeling miserable ( 29500382) Lymphocyte percentage of white cells ( 32888494) Monocyte percentage of white cells ( 32888494) Neurociticism ( 29500382) Neuroticism ( 29255261) Refractive error ( 32231278) Triglyceride levels ( 32203549)
Interacting Genes		19 interacting genes: ABL1 AR CUL4A CUL4B DCLRE1C DDB1 E2F1 H2AC20 H3C14 HDAC1 NR5A2 NTMT1 PAQR3 RAD51 TOP1 USP24 USP40 XPA XPC	25 interacting genes: AHR APP AR CAND1 COMMD1 DCUN1D4 DDB1 DDB2 DNMT3B ESR1 HUWE1 KPNA2 KPNA4 KPNB1 NEDD8 PRDX3 PTEN RBX1 RNF7 SALL2 SIN3A TBL3 UBC UBE2D3 ZMAT4
Entrez ID		1643	8450
HPRD ID		02886	02251
Ensembl ID		ENSG00000134574	ENSG00000158290
Uniprot IDs		Q92466	K4DI93 Q13620
PDB IDs		3EI4 3I7L 4E54 4E5Z 6R8Y 6R8Z 6R90 6R91 6R92	2DO7 4A0C 4A0L 4A64
Enriched GO Terms of Interacting Partners?
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