WNT11 and KRTAP1-3

Data Source:
BioGRID (two hybrid)

		WNT11	KRTAP1-3
Description		Wnt family member 11	keratin associated protein 1-3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Extracellular Matrix	Cytosol Keratin Filament
	Molecular Function	GTPase Activator Activity Frizzled Binding Cytokine Activity Protein Binding Protein Kinase Activator Activity	Structural Constituent Of Skin Epidermis
	Biological Process	Osteoblast Differentiation Epithelial To Mesenchymal Transition Primary Heart Field Specification Secondary Heart Field Specification Outflow Tract Morphogenesis Atrial Septum Development Planar Cell Polarity Pathway Involved In Axis Elongation Protein Phosphorylation Wnt Signaling Pathway, Calcium Modulating Pathway Positive Regulation Of Gene Expression Wnt Signaling Pathway Neuron Differentiation Bone Mineralization Negative Regulation Of Cell Growth Adrenal Gland Development Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Response To Nutrient Levels Activation Of Protein Kinase Activity Positive Regulation Of Transforming Growth Factor Beta2 Production Protein Localization To Cell Surface Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Cell Fate Commitment Maintenance Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Paraxial Mesoderm Formation Notochord Morphogenesis Embryonic Skeletal System Development Artery Morphogenesis Positive Regulation Of Stress Fiber Assembly Convergent Extension Involved In Axis Elongation Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Cloacal Septation Ventricular Septum Morphogenesis Lung-associated Mesenchyme Development Negative Regulation Of Cell Death Ureteric Bud Morphogenesis Planar Cell Polarity Pathway Involved In Gastrula Mediolateral Intercalation Negative Regulation Of Cartilage Development Somite Development Neuroendocrine Cell Differentiation Secondary Palate Development Bicellular Tight Junction Assembly Cellular Response To Mechanical Stimulus Cellular Response To Retinoic Acid Mesonephric Duct Development Negative Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Protein Kinase C Signaling Positive Regulation Of Heart Induction By Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Fibroblast Growth Factor Production	Biological_process Keratinization
Pathways		WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors) Ca2+ pathway Ca2+ pathway PCP/CE pathway PCP/CE pathway	Keratinization
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 30929738 31619474) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Platelet count ( 32888494) Plateletcrit ( 32888494) PR interval ( 30046033 32439900 20062060)
Interacting Genes		17 interacting genes: CCNDBP1 CYSRT1 FUCA2 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP17-1 KRTAP5-7 KRTAP5-8 KRTAP5-9 KRTAP9-3 MDFI RASSF10	176 interacting genes: ADAM12 AGA ALDH3B1 ALPP ATG9A BCAM BHLHE40 BMP7 BTC C19orf25 C2orf68 CATSPER1 CELF5 CHIC2 CHRD CHRNG CLDN2 CMTM8 CNNM3 COA5 COL8A1 CRCT1 CREB5 CRH CRY2 CTNNBIP1 CXCL16 CYHR1 CYP21A2 CYSRT1 DHRS1 DLGAP3 DMRT3 DOCK2 ECE1 FBXW5 GLP1R GLRX3 GNE GRAP2 GSTP1 HCK HHEX HHIPL1 HOXA1 HOXB9 HOXC8 HPCAL1 HSD3B7 IGSF8 IL10 IL16 INPP5D INS ITGB4 ITGB5 JOSD1 KLHL38 KPRP KRTAP10-1 KRTAP10-11 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LONRF1 LRFN4 MAPKBP1 MOS MTNR1A MXD3 MXI1 MYPOP NAXD NECTIN2 NECTIN3 NID2 NMU NPBWR2 NPDC1 NR1D2 NUFIP2 OLFM2 OTX1 P3H3 PDE9A PDIA5 PHETA1 PHLDA1 PIGS PLEKHN1 PRKAA2 PRKAB2 PRPF31 PSMA1 PTK7 PTPMT1 PVR R3HDM2 RAMAC RANBP3 RASD1 RPN1 RPS19BP1 SAPCD2 SDC3 SDCBP SELENOM SHFL SLC13A5 SLC22A23 SLC23A1 SLC39A7 SLC43A2 SLC7A11 SMCP SPINT1 SPRY1 STK16 SUSD6 TACSTD2 TCAF1 TFAP2D TGFB1 THAP7 TNS2 UNC119 UTP23 UXT VASN VSTM4 WNT11 XCL2 YIPF3 YY1 ZDHHC1 ZNF330 ZNF414 ZNF417 ZNF440 ZNF446 ZNF497 ZNF587 ZNF696 ZNF764 ZNF786 ZNF837
Entrez ID		7481	81850
HPRD ID		04741	12305
Ensembl ID		ENSG00000085741	ENSG00000221880
Uniprot IDs		O96014	Q8IUG1
PDB IDs
Enriched GO Terms of Interacting Partners?
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