WNT5A and ACVR2B

Data Source:
BioGRID (two hybrid)

		WNT5A	ACVR2B
Description		Wnt family member 5A	activin A receptor type 2B
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Clathrin-coated Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Collagen-containing Extracellular Matrix Extracellular Exosome Postsynapse Glutamatergic Synapse	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Protein-containing Complex Receptor Complex Activin Receptor Complex
	Molecular Function	Frizzled Binding Receptor Tyrosine Kinase-like Orphan Receptor Binding Cytokine Activity Protein Binding Phospholipid Binding Protein Domain Specific Binding Receptor Ligand Activity Chemoattractant Activity Involved In Axon Guidance	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Activin Receptor Activity, Type II Activin-activated Receptor Activity Growth Factor Binding Metal Ion Binding Activin Binding
	Biological Process	Activation Of MAPK Activity Establishment Of Planar Polarity Somitogenesis Kidney Development Epithelial To Mesenchymal Transition Positive Regulation Of Endothelial Cell Proliferation Heart Looping Positive Regulation Of Mesenchymal Cell Proliferation Lens Development In Camera-type Eye Positive Regulation Of Cytokine Production Involved In Immune Response Primary Heart Field Specification Secondary Heart Field Specification Atrial Septum Development Type B Pancreatic Cell Development Planar Cell Polarity Pathway Involved In Axis Elongation Optic Cup Formation Involved In Camera-type Eye Development Protein Phosphorylation Wnt Signaling Pathway, Calcium Modulating Pathway Activation Of JUN Kinase Activity Axon Guidance Hindgut Morphogenesis Midgut Development Male Gonad Development Anterior/posterior Axis Specification, Embryo Response To Organic Substance Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of T Cell Chemotaxis Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Olfactory Bulb Interneuron Development Neuron Differentiation Keratinocyte Differentiation Lung Development Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Protein Binding Activation Of Protein Kinase B Activity Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Protein Localization Non-canonical Wnt Signaling Pathway Post-anal Tail Morphogenesis Chemoattraction Of Serotonergic Neuron Axon Chemorepulsion Of Dopaminergic Neuron Axon Non-canonical Wnt Signaling Pathway Via JNK Cascade Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Wound Healing Embryonic Digit Morphogenesis Positive Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cell Fate Commitment Establishment Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Angiogenesis Positive Regulation Of Ossification Positive Regulation Of Endocytosis Positive Regulation Of Meiotic Nuclear Division Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Negative Regulation Of Melanin Biosynthetic Process Positive Regulation Of Fibroblast Proliferation Paraxial Mesoderm Formation Notochord Morphogenesis Embryonic Skeletal System Development Genitalia Development Negative Regulation Of Axon Extension Involved In Axon Guidance Hypophysis Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Regulation Of Synapse Organization Positive Regulation Of NF-kappaB Transcription Factor Activity Cartilage Development Positive Regulation Of Timing Of Anagen Negative Regulation Of Synapse Assembly Convergent Extension Involved In Axis Elongation Convergent Extension Involved In Organogenesis Uterus Development Cervix Development Vagina Development Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Urinary Bladder Development Face Development Positive Regulation Of Type I Interferon-mediated Signaling Pathway Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis Mesenchymal-epithelial Cell Signaling Negative Regulation Of Prostatic Bud Formation Mammary Gland Branching Involved In Thelarche Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Positive Regulation Of Response To Cytokine Stimulus Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Planar Cell Polarity Pathway Involved In Gastrula Mediolateral Intercalation Mesodermal To Mesenchymal Transition Involved In Gastrulation Positive Regulation Of Macrophage Cytokine Production Membrane Organization Positive Regulation Of Cartilage Development Planar Cell Polarity Pathway Involved In Outflow Tract Morphogenesis Planar Cell Polarity Pathway Involved In Ventricular Septum Morphogenesis Planar Cell Polarity Pathway Involved In Cardiac Right Atrium Morphogenesis Planar Cell Polarity Pathway Involved In Cardiac Muscle Tissue Morphogenesis Planar Cell Polarity Pathway Involved In Pericardium Morphogenesis Secondary Palate Development Positive Regulation Of Thymocyte Apoptotic Process Cellular Response To Lipopolysaccharide Cellular Response To Calcium Ion Cellular Response To Retinoic Acid Cellular Response To Interferon-gamma Hematopoietic Stem Cell Proliferation Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Mesenchymal Cell Proliferation Primitive Streak Formation Positive Regulation Of Protein Kinase C Signaling Positive Regulation Of Heart Induction By Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Activation Of GTPase Activity Melanocyte Proliferation Presynapse Assembly Postsynapse Assembly Regulation Of Postsynapse Organization Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Positive Regulation Of Neuron Projection Arborization Positive Regulation Of Protein Kinase C Activity Positive Regulation Of Neuron Death Positive Regulation Of Protein Localization To Synapse Regulation Of Cellular Protein Localization Excitatory Synapse Assembly Inhibitory Synapse Assembly Negative Regulation Of Cell Proliferation In Midbrain Planar Cell Polarity Pathway Involved In Axon Guidance Wnt Signaling Pathway Involved In Midbrain Dopaminergic Neuron Differentiation Planar Cell Polarity Pathway Involved In Midbrain Dopaminergic Neuron Differentiation Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Non-canonical Wnt Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Lymphangiogenesis Blood Vessel Remodeling Regulation Of Transcription, DNA-templated Protein Phosphorylation Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Anterior/posterior Pattern Specification Positive Regulation Of Bone Mineralization BMP Signaling Pathway Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Osteoblast Differentiation Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Retina Vasculature Development In Camera-type Eye Cellular Response To Growth Factor Stimulus Negative Regulation Of Cold-induced Thermogenesis
Pathways		TCF dependent signaling in response to WNT TCF dependent signaling in response to WNT WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors) Negative regulation of TCF-dependent signaling by WNT ligand antagonists Ca2+ pathway Ca2+ pathway PCP/CE pathway PCP/CE pathway Asymmetric localization of PCP proteins WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis WNT5:FZD7-mediated leishmania damping WNT5:FZD7-mediated leishmania damping	Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP
Drugs
Diseases			Heterotaxy; Situs ambiguus
GWAS		Carboplatin disposition in epthelial ovarian cancer ( 29367611) Height ( 28552196) Lung function (FEV1/FVC) ( 28166213) Metabolite levels ( 23823483) Type 2 diabetes ( 30130595)	Bitter beverage consumption ( 31046077) Body size at age 10 ( 32376654) Estimated glomerular filtration rate ( 31152163 31015462) P wave duration ( 24850809)
Interacting Genes		3 interacting genes: FZD1 FZD5 ROR2	21 interacting genes: ACVR1B BMP10 BMP2 BMP7 ERBIN FBXO7 GDF11 GDF2 GDF5 IGSF1 INHBA INHBB INHBC MSTN NODAL SNX1 SNX2 SNX6 SYNJ2BP TDGF1 TGFBRAP1
Entrez ID		7474	93
HPRD ID		01293	04106
Ensembl ID		ENSG00000114251	ENSG00000114739
Uniprot IDs		A0A024R316 A0A384N611 B3KQX9 P41221	Q13705
PDB IDs			2H62 2QLU 4FAO 5NGV 5NHR
Enriched GO Terms of Interacting Partners?
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