VTN and GLUD1

Data Source:
BioGRID (two hybrid)

		VTN	GLUD1
Description		vitronectin	glutamate dehydrogenase 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix Extracellular Exosome Alphav-beta3 Integrin-vitronectin Complex Blood Microparticle	Cytoplasm Mitochondrion Mitochondrial Matrix Endoplasmic Reticulum
	Molecular Function	Scavenger Receptor Activity Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Heparin Binding Polysaccharide Binding	Glutamate Dehydrogenase (NAD+) Activity Glutamate Dehydrogenase [NAD(P)+] Activity Protein Binding ATP Binding GTP Binding Identical Protein Binding ADP Binding NAD+ Binding Leucine Binding
	Biological Process	Endocytosis Immune Response Cell Adhesion Cell-matrix Adhesion Negative Regulation Of Endopeptidase Activity Positive Regulation Of Smooth Muscle Cell Migration Cell Migration Negative Regulation Of Blood Coagulation Extracellular Matrix Organization Regulation Of Complement Activation Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Binding Cell Adhesion Mediated By Integrin Endodermal Cell Differentiation Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Smooth Muscle Cell-matrix Adhesion Positive Regulation Of Wound Healing	Glutamate Biosynthetic Process Glutamate Catabolic Process Glutamine Metabolic Process Cellular Amino Acid Biosynthetic Process Substantia Nigra Development Positive Regulation Of Insulin Secretion Tricarboxylic Acid Metabolic Process
Pathways		Molecules associated with elastic fibres Integrin cell surface interactions Syndecan interactions ECM proteoglycans ECM proteoglycans Regulation of Complement cascade	Transcriptional activation of mitochondrial biogenesis Glutamate and glutamine metabolism
Drugs		Abciximab Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Glutamic acid NADH Hexachlorophene Guanosine-5'-Triphosphate Aluminum chloride
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Blood protein levels ( 29875488 28240269) Heel bone mineral density ( 30598549) LDL cholesterol ( 30275531) Low density lipoprotein cholesterol levels ( 32154731) Osteoprotegerin levels ( 25080503)	Renal underexcretion gout ( 32238385)
Interacting Genes		47 interacting genes: ADH5 ADTRP AMPH APP CBX1 CD247 CKS2 COPS5 CRADD CSNK2A1 DLG2 DLG3 EGF ETV7 FGF2 FGG GEM GLUD1 GOPC HGF IGF2 IGFBP5 ITGA8 ITGB3 ITGB6 ITGB8 KNG1 LACRT LNX2 PLAUR POMC PRDX4 PRKACA PRKCA PRKCB PRKCG PVR RHOXF1 RPL13A SERPINE1 SIX1 SNTG1 TGFB1 TGFB2 TNFRSF11B UBQLN2 VEGFA	11 interacting genes: ASGR2 CRP DYNLL1 GOT2 HPX HSD17B10 LSM1 NR4A1 ORM1 STAT5A VTN
Entrez ID		7448	2746
HPRD ID		01902	11748
Ensembl ID		ENSG00000109072	ENSG00000148672
Uniprot IDs		D9ZGG2 P04004	E9KL48 P00367
PDB IDs		1OC0 1S4G 1SSU 2JQ8 3BT1 3BT2 4K24 6O5E	1L1F 1NR1 6DQG
Enriched GO Terms of Interacting Partners?
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