VIPR1 and GNAI1

Data Source:
HPRD (in vitro)

		VIPR1	GNAI1
Description		vasoactive intestinal peptide receptor 1	G protein subunit alpha i1
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex	Nucleus Cytoplasm Lysosomal Membrane Centrosome Heterotrimeric G-protein Complex Plasma Membrane Midbody Membrane Raft Extracellular Exosome Cell Cortex Region
	Molecular Function	Vasoactive Intestinal Polypeptide Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding	Magnesium Ion Binding G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding GDP Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding GTPase Activating Protein Binding
	Biological Process	Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation	Protein Folding Cell Cycle G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Response To Peptide Hormone Regulation Of CAMP-mediated Signaling Negative Regulation Of Synaptic Transmission Cell Division Regulation Of Mitotic Spindle Organization Cellular Response To Forskolin Positive Regulation Of Protein Localization To Cell Cortex
Pathways		G alpha (s) signalling events Glucagon-type ligand receptors ADORA2B mediated anti-inflammatory cytokines production	PLC beta mediated events PLC beta mediated events Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G-protein activation ADP signalling through P2Y purinoceptor 12 Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events Regulation of insulin secretion Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production
Drugs			Guanosine-5'-Diphosphate Tetrafluoroaluminate Ion
Diseases
GWAS		Bipolar disorder ( 31043756) Cerebrospinal fluid clusterin levels ( 26545630) Hip circumference adjusted for BMI ( 28552196)	Cognitive decline rate in late mild cognitive impairment ( 26252872) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Night sleep phenotypes ( 27126917) Post bronchodilator FEV1 ( 26634245)
Interacting Genes		16 interacting genes: ADCYAP1 CALM1 GNAI1 GNAQ GNAS GPRASP1 PFN1 PRDM5 PTMA RAMP1 RAMP2 RAMP3 SCT TINF2 VIP WASL	62 interacting genes: ADCY5 ADRA2A ADRB2 CCR5 CD47 CNR1 CRHR1 CXCR4 DRD3 DRD4 EPOR ESR1 FFAR1 GNAO1 GNB2 GNB4 GNG2 GPR1 GPR143 GPSM1 GPSM2 GPSM3 HRH4 HTR2A IGF1R KLHL3 MTNR1A MTNR1B NGB NUCB1 NUMA1 OPRD1 OPRM1 PCP2 PDE6D PTEN PTPRU RANGAP1 RASD1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS20 RGS4 RGS7 RIC8A S1PR1 S1PR2 S1PR3 S1PR4 S1PR5 SSTR2 SSTR3 STRN THAP7 TSHR VIPR1 WASF1
Entrez ID		7433	2770
HPRD ID		01890	00756
Ensembl ID		ENSG00000114812	ENSG00000127955
Uniprot IDs		A0A024R2N2 B4DNY6 P32241	P63096
PDB IDs		1OF2 1OGT 3B3I 3B6S 3DTX 3HCV 5DEF 5DEG 5IB1 5IB2 5IB3 5IB4 5IB5 6VN7	1KJY 1Y3A 2G83 2GTP 2IK8 2OM2 2XNS 3ONW 3QE0 3QI2 3UMR 3UMS 4G5Q 5JS7 5JS8 5TDH 6CMO 6CRK 6DDE 6DDF 6KPF 6KPG 6LFM 6LFO 6LML 6N4B 6OMM 6OS9 6OSA 6OT0 6PB0 6PB1 6PT0 6QNO 6VU8 6XBJ 6XBK 6XBL 6XBM
Enriched GO Terms of Interacting Partners?
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