VIP and PRICKLE1

Data Source:
HPRD (in vivo)

		VIP	PRICKLE1
Description		vasoactive intestinal peptide	prickle planar cell polarity protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Neuron Projection Perikaryon	Nucleus Cytosol Nuclear Membrane
	Molecular Function	Hormone Activity Neuropeptide Hormone Activity Protein Binding Peptide Hormone Receptor Binding	Protein Binding Zinc Ion Binding
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Body Fluid Secretion Learning Or Memory Positive Regulation Of Cell Population Proliferation Positive Regulation Of Epinephrine Secretion Regulation Of Protein Localization Negative Regulation Of Apoptotic Process Negative Regulation Of Potassium Ion Transport Positive Regulation Of Protein Catabolic Process Epinephrine Secretion MRNA Stabilization Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Sensory Perception Of Pain Positive Regulation Of Penile Erection Prolactin Secretion	Neural Tube Closure Protein Import Into Nucleus Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Aorta Development Negative Regulation Of Transcription, DNA-templated Wnt Signaling Pathway, Planar Cell Polarity Pathway Coronary Vasculature Development Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation
Pathways		G alpha (s) signalling events Glucagon-type ligand receptors ADORA2B mediated anti-inflammatory cytokines production	Asymmetric localization of PCP proteins
Drugs
Diseases			Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Body mass index ( 26426971) Chronotype ( 30696823) Morning person ( 30696823) Morning vs. evening chronotype ( 26835600)	Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Blood urea nitrogen levels ( 31152163) Colorectal cancer ( 30529582 31826910) Endometrial cancer (Non-endometrioid histology) ( 30093612) Graves' disease ( 22922229) Heart failure ( 20445134) Hip circumference adjusted for BMI ( 28552196) Impulsivity (non-planning) ( 30718321) Inferior parietal cortex volume ( 31530798) Multiple sclerosis ( 31604244) Night sleep phenotypes ( 27126917) Parkinson's disease ( 27182965) Refractive error ( 32231278) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		11 interacting genes: CTNNA3 MEOX2 MEP1A MGST1 MME PRICKLE1 SGTA UBQLN2 UBQLN4 VIPR1 VIPR2	7 interacting genes: BYSL JRK KIF9 PRPF31 SMURF2 UTP14C VIP
Entrez ID		7432	144165
HPRD ID		15950	16341
Ensembl ID		ENSG00000146469	ENSG00000139174
Uniprot IDs		P01282	A0A024R0W7 B3KVG3 B3KVG6 Q96MT3
PDB IDs		2RRH 2RRI
Enriched GO Terms of Interacting Partners?
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