VIP and VIPR2

Data Source:
HPRD (in vivo, in vitro)

		VIP	VIPR2
Description		vasoactive intestinal peptide	vasoactive intestinal peptide receptor 2
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GO Annotations	Cellular Component	Extracellular Region Neuron Projection Perikaryon	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Hormone Activity Neuropeptide Hormone Activity Protein Binding Peptide Hormone Receptor Binding	G Protein-coupled Receptor Activity Vasoactive Intestinal Polypeptide Receptor Activity G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Body Fluid Secretion Learning Or Memory Positive Regulation Of Cell Population Proliferation Positive Regulation Of Epinephrine Secretion Regulation Of Protein Localization Negative Regulation Of Apoptotic Process Negative Regulation Of Potassium Ion Transport Positive Regulation Of Protein Catabolic Process Epinephrine Secretion MRNA Stabilization Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Sensory Perception Of Pain Positive Regulation Of Penile Erection Prolactin Secretion	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling
Pathways		G alpha (s) signalling events Glucagon-type ligand receptors ADORA2B mediated anti-inflammatory cytokines production	G alpha (s) signalling events Glucagon-type ligand receptors ADORA2B mediated anti-inflammatory cytokines production
Drugs
Diseases
GWAS		Body mass index ( 26426971) Chronotype ( 30696823) Morning person ( 30696823) Morning vs. evening chronotype ( 26835600)	Corneal astigmatism ( 30306274) Diastolic blood pressure x quantitative lifestyle risk score interaction (1df test) ( 32227373) Diastolic blood pressure x quantitative lifestyle risk score interaction (2df test) ( 32227373) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Myopia (pathological) ( 23406873) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Sub-foveal choroidal thickness ( 29844195)
Interacting Genes		11 interacting genes: CTNNA3 MEOX2 MEP1A MGST1 MME PRICKLE1 SGTA UBQLN2 UBQLN4 VIPR1 VIPR2	6 interacting genes: ADCYAP1 APP DBNDD2 ERBIN RGS14 VIP
Entrez ID		7432	7434
HPRD ID		15950	03576
Ensembl ID		ENSG00000146469	ENSG00000106018
Uniprot IDs		P01282	P41587 X5D7Q6 X5DP12
PDB IDs		2RRH 2RRI	2X57
Enriched GO Terms of Interacting Partners?
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