UCHL3 and PKD2

Data Source:
HPRD (in vitro)

		UCHL3	PKD2
Description		ubiquitin C-terminal hydrolase L3	polycystin 2, transient receptor potential cation channel
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Polycystin Complex Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Cilium Basal Plasma Membrane Membrane Lamellipodium Cytoplasmic Vesicle Membrane Motile Cilium Filamentous Actin Cation Channel Complex Ciliary Basal Body Basal Cortex Ciliary Membrane Extracellular Exosome Integral Component Of Cytoplasmic Side Of Endoplasmic Reticulum Membrane Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane Mitotic Spindle Non-motile Cilium
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Peptidase Activity NEDD8-specific Protease Activity Ubiquitin Binding	Signaling Receptor Binding Voltage-gated Ion Channel Activity Voltage-gated Calcium Channel Activity Voltage-gated Sodium Channel Activity Voltage-gated Potassium Channel Activity Cation Channel Activity Calcium Channel Activity Potassium Channel Activity Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Outward Rectifier Potassium Channel Activity Voltage-gated Cation Channel Activity Identical Protein Binding Protein Homodimerization Activity Actinin Binding HLH Domain Binding Ion Channel Binding Calcium-induced Calcium Release Activity ATPase Binding Phosphoprotein Binding Muscle Alpha-actinin Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Deubiquitination Protein Phosphopantetheinylation Protein Catabolic Process Post-translational Protein Modification	Branching Involved In Ureteric Bud Morphogenesis Liver Development Embryonic Placenta Development Heart Looping Detection Of Nodal Flow Calcium Ion Transport Cell Cycle Arrest Receptor Signaling Pathway Via JAK-STAT Determination Of Left/right Symmetry Heart Development Negative Regulation Of Cell Population Proliferation Wnt Signaling Pathway Spinal Cord Development Neural Tube Development Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Cellular Response To Reactive Oxygen Species Metanephric Part Of Ureteric Bud Development Sodium Ion Transmembrane Transport Aorta Development Regulation Of Cell Population Proliferation Cytoplasmic Sequestering Of Transcription Factor Cilium Organization Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Detection Of Mechanical Stimulus Release Of Sequestered Calcium Ion Into Cytosol Protein Tetramerization Protein Homotetramerization Protein Heterotetramerization Centrosome Duplication Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Placenta Blood Vessel Development Renal Tubule Morphogenesis Renal Artery Morphogenesis Calcium Ion Transmembrane Transport Positive Regulation Of Cell Cycle Arrest Cellular Response To Calcium Ion Cellular Response To CAMP Cellular Response To Hydrostatic Pressure Cellular Response To Osmotic Stress Cellular Response To Fluid Shear Stress Potassium Ion Transmembrane Transport Determination Of Liver Left/right Asymmetry Metanephric Mesenchyme Development Mesonephric Tubule Development Mesonephric Duct Development Metanephric Smooth Muscle Tissue Development Metanephric Cortex Development Metanephric Ascending Thin Limb Development Metanephric Cortical Collecting Duct Development Metanephric Distal Tubule Development Metanephric S-shaped Body Morphogenesis Regulation Of Calcium Ion Import Inorganic Cation Transmembrane Transport Cell-cell Signaling By Wnt Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		UCH proteinases Synthesis of active ubiquitin: roles of E1 and E2 enzymes Neddylation	VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium
Drugs
Diseases			Polycystic kidney disease
GWAS		Diabetic retinopathy ( 23562823) Metabolite levels ( 23823483)	Coffee consumption (cups per day) ( 25288136) Dental caries ( 23064961) Gout ( 30899057) Hyperuricemia ( 28776340) Serum uric acid levels in response to allopurinol in gout ( 25676789) Uric acid levels ( 29558500)
Interacting Genes		20 interacting genes: ATM ATXN7L3 CDH1 FOXM1 LONRF1 NEDD8 NSG2 PJA1 PLA2G2A POGK RAD51 TRIM27 TRIM54 TRIM55 TRIM63 UBE2S USP15 USP21 USP28 XRCC5	21 interacting genes: ACTN2 CD2AP CYSRT1 DIAPH1 HAX1 HSF2BP KRT40 KRTAP10-3 KRTAP10-8 KRTAP6-2 LMNA MAGEA8 MDFI PACS1 PACS2 PKD1 PLSCR1 PTPRG TNNI3 TPM1 TRPC1
Entrez ID		7347	5311
HPRD ID		04367	01437
Ensembl ID		ENSG00000118939	ENSG00000118762
Uniprot IDs		A0A087WTB8 A0A140VJZ4 P15374	Q13563 Q9UEU6
PDB IDs		1UCH 1XD3 6ISU 6QML	2KLD 2KLE 2KQ6 2Y4Q 3HRN 3HRO 5K47 5MKE 5MKF 5T4D 6A70 6D1W 6T9N 6T9O 6WB8
Enriched GO Terms of Interacting Partners?
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