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C8G and UBQLN2
Data Source:
BioGRID
(two hybrid)
C8G
UBQLN2
Description
complement C8 gamma chain
ubiquilin 2
Image
GO Annotations
Cellular Component
Extracellular Region
Membrane Attack Complex
Extracellular Exosome
Blood Microparticle
Nucleus
Cytoplasm
Autophagosome
Cytosol
Plasma Membrane
Cytoplasmic Vesicle
Molecular Function
Complement Binding
Protein Binding
Retinol Binding
Protein-containing Complex Binding
Protein Binding
Polyubiquitin Modification-dependent Protein Binding
Identical Protein Binding
Biological Process
Complement Activation, Alternative Pathway
Complement Activation, Classical Pathway
Cytolysis
Regulation Of Complement Activation
Autophagosome Assembly
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Macroautophagy
Ubiquitin-dependent ERAD Pathway
Negative Regulation Of Clathrin-dependent Endocytosis
Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of G Protein-coupled Receptor Internalization
Regulation Of Autophagosome Assembly
Pathways
Terminal pathway of complement
Regulation of Complement cascade
Cargo recognition for clathrin-mediated endocytosis
Drugs
Zinc
Lauric acid
Citric acid
Zinc acetate
Diseases
Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency
GWAS
Blood protein levels (
29875488
)
Interacting Genes
2 interacting genes:
C8A
UBQLN2
262 interacting genes:
ABI2
ACOT7
ADAMTS3
ADRM1
AGR2
AGR3
AMBN
ANKRD33
APOC2
APOC4
ARRDC3
ASCL1
ATXN7
AZGP1
BAG6
BCL2L11
BPIFA1
BTRC
C1orf94
C1QA
C1QB
C1QC
C1QL4
C1QTNF2
C1QTNF4
C6orf15
C8G
CAPN15
CCDC158
CCK
CCL16
CCL3
CCL7
CCN1
CD93
CD99L2
CDH15
CDH17
CDIP1
CDSN
CEACAM6
CLEC11A
CLPSL2
CNNM3
COL10A1
COL17A1
COL1A2
COL8A1
COL9A2
COLGALT2
CSN1S1
CSN2
CSN3
CST1
CST4
CSTF2
CSTF2T
CTAG1A
CTAG1B
CTDNEP1
DAZAP2
DDR1
DEFA1
DEFA1B
DEFA6
DEFB115
DESI1
DMKN
DUSP21
ECM1
ECRG4
EFEMP1
EGFL6
ERP27
ERP29
ETNK1
F10
FAM168A
FAM222B
FBXO25
FDCSP
FGF17
FKBP2
FNDC11
FUCA1
FUS
FZD7
GAL
GALP
GHRL
GPR162
GPX7
GUCA2A
GUCA2B
HEMK1
HERC3
HERPUD1
HGS
HNRNPA3
HSD17B12
HSPA13
ICAM1
IFNA13
IGFBP6
IGLL1
IL11
IQCF3
IST1
ITPKB
ITPRIPL1
JPH4
KISS1
KLHL11
KLHL42
KRT6A
KRTAP12-1
KRTAP13-1
KRTAP19-3
KRTAP19-5
LAIR2
LASP1
LATS1
LCN1
LCN2
LITAF
LMO4
LY6G6D
MAGED1
MBL2
MDK
MICOS10-NBL1
MIEF1
MIEF2
MINPP1
MOAP1
MTNR1B
MTX2
MYDGF
MYO15B
NAXD
NBL1
NDOR1
NME3
NOC4L
NOL3
NPBWR1
NPPA
NPVF
NPY
NRN1L
NT5C3A
NUP58
ODAPH
OPN4
OR7D4
OSMR
PARM1
PCDHGA9
PIANP
PIK3IP1
PIN1
PLAAT2
PLAAT3
PLEKHB2
PMEPA1
PNMA3
PODXL
POLE2
POM121
PPIB
PPIC
PPIH
PRAP1
PRPF40A
PRR4
PSMA2
PSMA5
PSMD2
PSMD4
PSORS1C2
PTGDS
QPCT
RAD23A
RAD23B
RASSF5
RBFOX2
RBM24
RNF11
RNF128
RNF208
RNF4
RPN1
RPS27A
RSRC2
RTL8A
RTL8B
RTL8C
SCG5
SCGB2B2
SEMG1
SERPINE1
SERPINI2
SEZ6
SEZ6L
SFTPA2
SGTA
SLC16A3
SLC29A2
SLITRK1
SLPI
SMIM11A
SMIM11B
SMIM19
SMIM2
SMR3B
SMURF1
SNRPB
SOD3
SPAG11B
SPINT1
SPN
SRGN
SRP68
STAM2
SUOX
SUSD4
TENT5B
TFF3
TIMM21
TIMP2
TMEM123
TMEM31
TNFRSF18
TOMM20L
TRAF4
TRIM32
TXNDC12
TXNDC5
UACA
UBA52
UBAC1
UBB
UBC
UBE2I
UBE2V1
UBE3A
UBQLN1
UBQLN4
UBXN1
UBXN7
UFSP1
VENTX
VIP
VTN
VWC2
WFDC10B
WFDC12
ZFAND2A
ZFAND2B
ZG16
ZG16B
ZNF205
Entrez ID
733
29978
HPRD ID
00407
02224
Ensembl ID
ENSG00000176919
ENSG00000188021
Uniprot IDs
P07360
Q9UHD9
PDB IDs
1IW2
1LF7
2OVA
2OVD
2OVE
2QOS
2RD7
3OJY
6H03
6H04
1J8C
2NBV
6MUN
Enriched GO Terms of Interacting Partners
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