UBQLN2 and FUS

Data Source:
BioGRID (affinity chromatography technology, pull down)

		UBQLN2	FUS
Description		ubiquilin 2	FUS RNA binding protein
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GO Annotations	Cellular Component	Nucleus Cytoplasm Autophagosome Cytosol Plasma Membrane Cytoplasmic Vesicle	Nucleus Nucleoplasm
	Molecular Function	Protein Binding Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding	DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity RNA Binding Protein Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Autophagosome Assembly Ubiquitin-dependent Protein Catabolic Process Regulation Of Macroautophagy Ubiquitin-dependent ERAD Pathway Negative Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of G Protein-coupled Receptor Internalization Regulation Of Autophagosome Assembly	MRNA Splicing, Via Spliceosome Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II RNA Splicing Regulation Of RNA Splicing Positive Regulation Of Transcription, DNA-templated MRNA Stabilization Protein Homooligomerization Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		Cargo recognition for clathrin-mediated endocytosis	mRNA Splicing - Major Pathway
Drugs
Diseases			Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Myxoid liposarcoma
GWAS			Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) HDL cholesterol levels ( 32203549)
Interacting Genes		262 interacting genes: ABI2 ACOT7 ADAMTS3 ADRM1 AGR2 AGR3 AMBN ANKRD33 APOC2 APOC4 ARRDC3 ASCL1 ATXN7 AZGP1 BAG6 BCL2L11 BPIFA1 BTRC C1orf94 C1QA C1QB C1QC C1QL4 C1QTNF2 C1QTNF4 C6orf15 C8G CAPN15 CCDC158 CCK CCL16 CCL3 CCL7 CCN1 CD93 CD99L2 CDH15 CDH17 CDIP1 CDSN CEACAM6 CLEC11A CLPSL2 CNNM3 COL10A1 COL17A1 COL1A2 COL8A1 COL9A2 COLGALT2 CSN1S1 CSN2 CSN3 CST1 CST4 CSTF2 CSTF2T CTAG1A CTAG1B CTDNEP1 DAZAP2 DDR1 DEFA1 DEFA1B DEFA6 DEFB115 DESI1 DMKN DUSP21 ECM1 ECRG4 EFEMP1 EGFL6 ERP27 ERP29 ETNK1 F10 FAM168A FAM222B FBXO25 FDCSP FGF17 FKBP2 FNDC11 FUCA1 FUS FZD7 GAL GALP GHRL GPR162 GPX7 GUCA2A GUCA2B HEMK1 HERC3 HERPUD1 HGS HNRNPA3 HSD17B12 HSPA13 ICAM1 IFNA13 IGFBP6 IGLL1 IL11 IQCF3 IST1 ITPKB ITPRIPL1 JPH4 KISS1 KLHL11 KLHL42 KRT6A KRTAP12-1 KRTAP13-1 KRTAP19-3 KRTAP19-5 LAIR2 LASP1 LATS1 LCN1 LCN2 LITAF LMO4 LY6G6D MAGED1 MBL2 MDK MICOS10-NBL1 MIEF1 MIEF2 MINPP1 MOAP1 MTNR1B MTX2 MYDGF MYO15B NAXD NBL1 NDOR1 NME3 NOC4L NOL3 NPBWR1 NPPA NPVF NPY NRN1L NT5C3A NUP58 ODAPH OPN4 OR7D4 OSMR PARM1 PCDHGA9 PIANP PIK3IP1 PIN1 PLAAT2 PLAAT3 PLEKHB2 PMEPA1 PNMA3 PODXL POLE2 POM121 PPIB PPIC PPIH PRAP1 PRPF40A PRR4 PSMA2 PSMA5 PSMD2 PSMD4 PSORS1C2 PTGDS QPCT RAD23A RAD23B RASSF5 RBFOX2 RBM24 RNF11 RNF128 RNF208 RNF4 RPN1 RPS27A RSRC2 RTL8A RTL8B RTL8C SCG5 SCGB2B2 SEMG1 SERPINE1 SERPINI2 SEZ6 SEZ6L SFTPA2 SGTA SLC16A3 SLC29A2 SLITRK1 SLPI SMIM11A SMIM11B SMIM19 SMIM2 SMR3B SMURF1 SNRPB SOD3 SPAG11B SPINT1 SPN SRGN SRP68 STAM2 SUOX SUSD4 TENT5B TFF3 TIMM21 TIMP2 TMEM123 TMEM31 TNFRSF18 TOMM20L TRAF4 TRIM32 TXNDC12 TXNDC5 UACA UBA52 UBAC1 UBB UBC UBE2I UBE2V1 UBE3A UBQLN1 UBQLN4 UBXN1 UBXN7 UFSP1 VENTX VIP VTN VWC2 WFDC10B WFDC12 ZFAND2A ZFAND2B ZG16 ZG16B ZNF205	117 interacting genes: ADAMTS9-AS2 AKT1 ARID1A ATXN1L CTNNB1 ESRRA EWSR1 GRIN1 GRIN2D IL7R ILF3 KHDRBS3 MAX MDH1 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NKD2 POLR2A PRMT1 PSMB7 PTBP1 RBMX RELA RXRA SAFB2 SF1 SFPQ SMARCB1 SMARCC1 SMARCC2 SMARCD1 SPI1 SRRM1 SRSF10 SRSF2 SRSF4 SRSF9 SS18 SUV39H1 TARDBP TDRD3 THRA TNIP1 UBQLN2 WBP4 YBX1 ZMYM2
Entrez ID		29978	2521
HPRD ID		02224	00660
Ensembl ID		ENSG00000188021	ENSG00000089280
Uniprot IDs		Q9UHD9	P35637 Q13344 Q6IBQ5
PDB IDs		1J8C 2NBV 6MUN	2LA6 2LCW 4FDD 4FQ3 5W3N 5XRR 5XSG 5YVG 5YVH 5YVI 6BWZ 6BXV 6BZP 6G99 6GBM 6KJ1 6KJ2 6KJ3 6KJ4 6SNJ 6XFM
Enriched GO Terms of Interacting Partners?
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