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UBQLN2 and HGS
Data Source:
BioGRID
(two hybrid)
UBQLN2
HGS
Description
ubiquilin 2
hepatocyte growth factor-regulated tyrosine kinase substrate
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Autophagosome
Cytosol
Plasma Membrane
Cytoplasmic Vesicle
Lysosome
Endosome
Early Endosome
Cytosol
Early Endosome Membrane
Multivesicular Body Membrane
ESCRT-0 Complex
Intracellular Membrane-bounded Organelle
Extracellular Exosome
Molecular Function
Protein Binding
Polyubiquitin Modification-dependent Protein Binding
Identical Protein Binding
Protein Binding
Protein Domain Specific Binding
Ubiquitin-like Protein Ligase Binding
Metal Ion Binding
Biological Process
Autophagosome Assembly
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Macroautophagy
Ubiquitin-dependent ERAD Pathway
Negative Regulation Of Clathrin-dependent Endocytosis
Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of G Protein-coupled Receptor Internalization
Regulation Of Autophagosome Assembly
Protein Targeting To Lysosome
Signal Transduction
Negative Regulation Of Cell Population Proliferation
Membrane Invagination
Positive Regulation Of Gene Expression
Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Endosomal Transport
Macroautophagy
Negative Regulation Of Angiogenesis
Protein Deubiquitination
Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Multivesicular Body Assembly
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Protein Catabolic Process
Regulation Of MAP Kinase Activity
Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Membrane Organization
Protein Localization To Membrane
Positive Regulation Of Exosomal Secretion
Pathways
Cargo recognition for clathrin-mediated endocytosis
EGFR downregulation
Lysosome Vesicle Biogenesis
Ub-specific processing proteases
Negative regulation of MET activity
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
InlB-mediated entry of Listeria monocytogenes into host cell
Endosomal Sorting Complex Required For Transport (ESCRT)
Inhibition of membrane repair
Prevention of phagosomal-lysosomal fusion
RHOBTB3 ATPase cycle
Drugs
Citric acid
Diseases
GWAS
Eye color traits (
20463881
)
Refractive error (
32231278
)
Interacting Genes
262 interacting genes:
ABI2
ACOT7
ADAMTS3
ADRM1
AGR2
AGR3
AMBN
ANKRD33
APOC2
APOC4
ARRDC3
ASCL1
ATXN7
AZGP1
BAG6
BCL2L11
BPIFA1
BTRC
C1orf94
C1QA
C1QB
C1QC
C1QL4
C1QTNF2
C1QTNF4
C6orf15
C8G
CAPN15
CCDC158
CCK
CCL16
CCL3
CCL7
CCN1
CD93
CD99L2
CDH15
CDH17
CDIP1
CDSN
CEACAM6
CLEC11A
CLPSL2
CNNM3
COL10A1
COL17A1
COL1A2
COL8A1
COL9A2
COLGALT2
CSN1S1
CSN2
CSN3
CST1
CST4
CSTF2
CSTF2T
CTAG1A
CTAG1B
CTDNEP1
DAZAP2
DDR1
DEFA1
DEFA1B
DEFA6
DEFB115
DESI1
DMKN
DUSP21
ECM1
ECRG4
EFEMP1
EGFL6
ERP27
ERP29
ETNK1
F10
FAM168A
FAM222B
FBXO25
FDCSP
FGF17
FKBP2
FNDC11
FUCA1
FUS
FZD7
GAL
GALP
GHRL
GPR162
GPX7
GUCA2A
GUCA2B
HEMK1
HERC3
HERPUD1
HGS
HNRNPA3
HSD17B12
HSPA13
ICAM1
IFNA13
IGFBP6
IGLL1
IL11
IQCF3
IST1
ITPKB
ITPRIPL1
JPH4
KISS1
KLHL11
KLHL42
KRT6A
KRTAP12-1
KRTAP13-1
KRTAP19-3
KRTAP19-5
LAIR2
LASP1
LATS1
LCN1
LCN2
LITAF
LMO4
LY6G6D
MAGED1
MBL2
MDK
MICOS10-NBL1
MIEF1
MIEF2
MINPP1
MOAP1
MTNR1B
MTX2
MYDGF
MYO15B
NAXD
NBL1
NDOR1
NME3
NOC4L
NOL3
NPBWR1
NPPA
NPVF
NPY
NRN1L
NT5C3A
NUP58
ODAPH
OPN4
OR7D4
OSMR
PARM1
PCDHGA9
PIANP
PIK3IP1
PIN1
PLAAT2
PLAAT3
PLEKHB2
PMEPA1
PNMA3
PODXL
POLE2
POM121
PPIB
PPIC
PPIH
PRAP1
PRPF40A
PRR4
PSMA2
PSMA5
PSMD2
PSMD4
PSORS1C2
PTGDS
QPCT
RAD23A
RAD23B
RASSF5
RBFOX2
RBM24
RNF11
RNF128
RNF208
RNF4
RPN1
RPS27A
RSRC2
RTL8A
RTL8B
RTL8C
SCG5
SCGB2B2
SEMG1
SERPINE1
SERPINI2
SEZ6
SEZ6L
SFTPA2
SGTA
SLC16A3
SLC29A2
SLITRK1
SLPI
SMIM11A
SMIM11B
SMIM19
SMIM2
SMR3B
SMURF1
SNRPB
SOD3
SPAG11B
SPINT1
SPN
SRGN
SRP68
STAM2
SUOX
SUSD4
TENT5B
TFF3
TIMM21
TIMP2
TMEM123
TMEM31
TNFRSF18
TOMM20L
TRAF4
TRIM32
TXNDC12
TXNDC5
UACA
UBA52
UBAC1
UBB
UBC
UBE2I
UBE2V1
UBE3A
UBQLN1
UBQLN4
UBXN1
UBXN7
UFSP1
VENTX
VIP
VTN
VWC2
WFDC10B
WFDC12
ZFAND2A
ZFAND2B
ZG16
ZG16B
ZNF205
328 interacting genes:
ABI2
ACLY
ACOT11
ACTN3
ADRA2C
AHCYL1
AKAP8L
ANKRD55
ANTKMT
APC
APLP2
APP
ARFIP2
ARL6IP1
ARMC7
ASB12
ATN1
ATP1A1
ATP2A2
ATXN1L
BBC3
BCAS2
BEGAIN
BFSP2
BICRAL
BLOC1S1
BORCS6
BRINP3
BSG
C11orf1
C1orf94
C20orf173
C3orf36
C9orf24
CASK
CBS
CCDC103
CCDC136
CCDC196
CCDC33
CCND3
CDR2
CDSN
CEACAM6
CEP55
CEP57L1
CEP63
CEP68
CLTC
COG8
CRMP1
CRX
CSNK2A1
CSTF2
CSTF2T
CTTNBP2NL
CYB5R2
DAAM2
DAZAP2
DCTN2
DECR1
DEUP1
DGCR6
DLG4
DNAJC5
DSN1
DTX2
DYDC1
EFHC2
EGFL7
EGFR
EHMT2
EIF3F
EPS15
ESRRG
EXOC3L1
EXOC5
EXOC7
EXOC8
EYA2
FAM166A
FAM168A
FAM185A
FANCG
FBN1
FCHSD2
FIGN
FLOT1
FLOT2
FNDC11
FOXD4L1
FOXI1
FSD2
FTCD
GATC
GFAP
GFI1B
GGA2
GKAP1
GOLGA2
GOLGA6L9
GOLGA7B
GUCA1C
HAP1
HAUS1
HNRNPDL
HNRNPM
HSF4
HSFY1
HSPA8
ICA1L
IFNA16
IFT74
IL2RB
IL4R
ILKAP
ING5
INTS4
IPO4
JAKMIP2
JMJD7
KIAA0753
KIAA0825
KLF4
KRT13
KRT14
KRT15
KRT16
KRT18
KRT19
KRT24
KRT25
KRT26
KRT27
KRT3
KRT31
KRT33B
KRT34
KRT35
KRT36
KRT37
KRT38
KRT39
KRT40
KRT6A
KRT75
KRT76
KRT82
KRT86
KRTAP19-5
KRTAP26-1
KRTAP7-1
LASP1
LDOC1
LINC00265
LITAF
LMO1
LMO4
LRRC61
LURAP1
LYST
MAGEB4
MAGED1
MAP3K1
MAP3K10
MAP3K7
MAPK1IP1L
MARK4
MAT2A
MED21
MED22
MED25
MED30
MED4
MED7
MEIS3
MEST
MET
METTL27
MIF4GD
MKNK1
MKRN3
MRFAP1L1
MTHFD1L
NADSYN1
NDC80
NDUFB10
NEDD4
NEDD8
NEFL
NF2
NFYC
NMI
NPAS2
NUP54
NUP62
NUTM2F
ODAD1
ODAM
OIP5
OSBPL5
P4HA3
PAK1
PAX5
PAX6
PEF1
PELP1
PFKM
PIK3R1
PITX1
PKNOX2
PLA2G10
PLAAT1
PLCD1
PLD3
PLEKHB2
PMEPA1
PNMA1
POGZ
POU2AF1
POU6F2
PPP1R16A
PPP1R32
PPP1R7
PPP2R3B
PRR22
PRR5
PSMB11
PSMB4
PTCD3
RASSF4
RBCK1
RFC2
RFX6
RHOBTB3
RINT1
RNF4
RPRD1A
RPS3A
RSPO4
RSU1
RUNX1
SAPCD1
SCAMP3
SCRN1
SCT
SDS
SERGEF
SERTAD3
SF3B3
SMAD2
SMAD3
SMAD5
SMARCB1
SNAP25
SNX1
SNX5
SNX7
SORBS3
SPATA12
SPC25
SPIRE2
SS18L1
STAM
STAM2
STK32C
STMN3
STX11
STXBP1
SUMO1
SUN2
SYK
TADA2A
TASOR2
TBX19
TCP11L2
TEKT1
TEKT5
TFG
TIMM10B
TIMMDC1
TJP2
TLE5
TMCC2
TOM1L1
TP53BP1
TRAF1
TRAF4
TRAK1
TRAP1
TRIM10
TRIM17
TRIM23
TRIM27
TRIM54
TRIM69
TRIM73
TRIML2
TSG101
TUBB
TUBB2A
UBA1
UBA52
UBAP2
UBB
UBC
UBE2I
UBE4B
UBQLN1
UBQLN2
UBQLN4
UBQLNL
UBXN11
USHBP1
USP54
VGLL3
VMP1
VPS37A
VPS37B
VPS37C
VPS37D
VPS52
WASHC1
YPEL3
ZNF302
ZNF34
ZNF430
ZNF44
Entrez ID
29978
9146
HPRD ID
02224
05085
Ensembl ID
ENSG00000188021
ENSG00000185359
Uniprot IDs
Q9UHD9
A0A0S2Z4R4
O14964
PDB IDs
1J8C
2NBV
6MUN
2D3G
3F1I
3OBQ
3ZYQ
4AVX
Enriched GO Terms of Interacting Partners
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