EPS15 and FCHO2

Data Source:
BioGRID (pull down)

		EPS15	FCHO2
Description		epidermal growth factor receptor pathway substrate 15	FCH and mu domain containing endocytic adaptor 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit Basal Plasma Membrane Membrane Aggresome Apical Plasma Membrane Clathrin Coat Of Coated Pit Early Endosome Membrane Intracellular Membrane-bounded Organelle Postsynapse Glutamatergic Synapse	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Clathrin-coated Pit Clathrin-coated Vesicle Presynaptic Endocytic Zone Membrane
	Molecular Function	Calcium Ion Binding Protein Binding SH3 Domain Binding Polyubiquitin Modification-dependent Protein Binding Cadherin Binding	Phosphatidylserine Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol Binding Identical Protein Binding
	Biological Process	Positive Regulation Of Receptor Recycling Golgi To Endosome Transport Endocytosis Vesicle Organization Endosomal Transport Receptor-mediated Endocytosis Of Virus By Host Cell Endocytic Recycling Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Population Proliferation Viral Entry Into Host Cell Clathrin Coat Assembly Membrane Organization Postsynaptic Neurotransmitter Receptor Internalization	Membrane Invagination Clathrin Coat Assembly Synaptic Vesicle Endocytosis Membrane Organization Clathrin-dependent Endocytosis Protein Localization To Plasma Membrane
Pathways		EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Blood urea nitrogen levels ( 31152163) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) IgE grass sensitization ( 22036096) PR interval ( 30046033 32439900)	Albumin-globulin ratio ( 29403010) Aspartate aminotransferase levels ( 29403010) Discordance in emotional problems in monozygotic twins ( 27043157) Eyebrow thickness ( 26926045) Factor VIII levels ( 30586737) Heel bone mineral density ( 30598549) Immunoglobulin measurement (zinc sulfate turbidity test) ( 29403010) Mean corpuscular hemoglobin concentration ( 32888494) Mean platelet volume ( 32888494) Monobrow thickness ( 26926045) Non-albumin protein levels ( 29403010) Red cell distribution width ( 32888494 27863252) Serum albumin level ( 29403010) Small cell lung carcinoma ( 28604730) vWF levels ( 30586737)
Interacting Genes		49 interacting genes: AGFG1 AGFG2 AP1G1 AP2A1 AP2A2 CLINT1 CORO7 CRK DNM1 DNM2 EGFR ELF3 EPN1 EPN2 FCHO1 FCHO2 GRB2 HGS ITSN1 LAPTM5 MAPK14 MOB4 MTNR1A NAGPA NEDD4 NUMB NUMBL PRKN REPS2 RNF11 SCAMP1 SGIP1 SNAP91 SPART SPOPL STAM2 STAMBP STON2 SYNJ1 TFAP2A UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H UBQLN1 USP8	6 interacting genes: DAB2 EPS15 EPS15L1 ITSN1 RHOU UBC
Entrez ID		2060	115548
HPRD ID		08968	13319
Ensembl ID		ENSG00000085832	ENSG00000157107
Uniprot IDs		B7Z240 P42566	Q0JRZ9
PDB IDs		1C07 1EH2 1F8H 1FF1 2IV9 2JXC 4RH5 4RH9 4RHG 4S0G 5AWT 5AWU 5JP2	2V0O
Enriched GO Terms of Interacting Partners?
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