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EPS15 and UBE2E1
Data Source:
BioGRID
(enzymatic study)
EPS15
UBE2E1
Description
epidermal growth factor receptor pathway substrate 15
ubiquitin conjugating enzyme E2 E1
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
Clathrin-coated Pit
Basal Plasma Membrane
Membrane
Aggresome
Apical Plasma Membrane
Clathrin Coat Of Coated Pit
Early Endosome Membrane
Intracellular Membrane-bounded Organelle
Postsynapse
Glutamatergic Synapse
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytosol
Molecular Function
Calcium Ion Binding
Protein Binding
SH3 Domain Binding
Polyubiquitin Modification-dependent Protein Binding
Cadherin Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
ISG15 Transferase Activity
Ubiquitin Conjugating Enzyme Activity
Biological Process
Positive Regulation Of Receptor Recycling
Golgi To Endosome Transport
Endocytosis
Vesicle Organization
Endosomal Transport
Receptor-mediated Endocytosis Of Virus By Host Cell
Endocytic Recycling
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Cell Population Proliferation
Viral Entry Into Host Cell
Clathrin Coat Assembly
Membrane Organization
Postsynaptic Neurotransmitter Receptor Internalization
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Histone Monoubiquitination
Protein Ubiquitination
Protein Phosphopantetheinylation
Anaphase-promoting Complex-dependent Catabolic Process
ISG15-protein Conjugation
Histone H2B Ubiquitination
Protein K48-linked Ubiquitination
Regulation Of Mitotic Cell Cycle Phase Transition
Pathways
EGFR downregulation
Negative regulation of MET activity
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
InlB-mediated entry of Listeria monocytogenes into host cell
ISG15 antiviral mechanism
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
E3 ubiquitin ligases ubiquitinate target proteins
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Blood urea nitrogen levels (
31152163
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
IgE grass sensitization (
22036096
)
PR interval (
30046033
32439900
)
Acne (severe) (
24927181
)
Extremely high intelligence (
29520040
)
Metabolite levels (
23823483
)
Interacting Genes
49 interacting genes:
AGFG1
AGFG2
AP1G1
AP2A1
AP2A2
CLINT1
CORO7
CRK
DNM1
DNM2
EGFR
ELF3
EPN1
EPN2
FCHO1
FCHO2
GRB2
HGS
ITSN1
LAPTM5
MAPK14
MOB4
MTNR1A
NAGPA
NEDD4
NUMB
NUMBL
PRKN
REPS2
RNF11
SCAMP1
SGIP1
SNAP91
SPART
SPOPL
STAM2
STAMBP
STON2
SYNJ1
TFAP2A
UBB
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2H
UBQLN1
USP8
114 interacting genes:
ARIH2
ASXL2
BARD1
BIRC7
BIRC8
BRCA1
CADPS2
CBL
CBWD5
CHFR
CNOT4
CUL3
DTX1
DTX3
DTX3L
DZIP3
EPS15
F12
FBXL17
FBXO2
FBXO7
H3C1
H4C1
HDAC6
IPO11
ITCH
JADE1
LRSAM1
MAP3K1
MARCHF3
MARCHF5
MARCHF7
MDM2
MGRN1
MID1
MKRN3
MUL1
NEDD4
NEDD4L
NHLRC1
PAEP
PBX2
POLL
POLM
PRKN
RBX1
RELA
RFWD3
RLIM
RMND5B
RNF10
RNF103
RNF11
RNF111
RNF114
RNF115
RNF122
RNF128
RNF13
RNF130
RNF14
RNF150
RNF152
RNF165
RNF166
RNF167
RNF168
RNF169
RNF181
RNF185
RNF2
RNF20
RNF26
RNF31
RNF4
RNF40
RNF43
RNF5
RNF8
STUB1
TOPORS
TRAF6
TRIM17
TRIM2
TRIM21
TRIM23
TRIM27
TRIM28
TRIM29
TRIM3
TRIM32
TRIM33
TRIM37
TRIM38
TRIM39
TRIM45
TRIM50
TRIM69
TRIM7
UBA1
UBA7
UBASH3B
UBE2G1
UBE3A
UBOX5
UBR7
UFM1
USP7
UVSSA
WWP2
XIAP
ZNRF1
ZNRF2
ZNRF4
Entrez ID
2060
7324
HPRD ID
08968
04225
Ensembl ID
ENSG00000085832
ENSG00000170142
Uniprot IDs
B7Z240
P42566
A0A024R2K3
B7Z306
P51965
PDB IDs
1C07
1EH2
1F8H
1FF1
2IV9
2JXC
4RH5
4RH9
4RHG
4S0G
5AWT
5AWU
5JP2
1XR9
3BZH
4JJQ
5LBN
6FGA
Enriched GO Terms of Interacting Partners
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