TYMS and SH3GL2

Data Source:
BioGRID (two hybrid)

		TYMS	SH3GL2
Description		thymidylate synthetase	SH3 domain containing GRB2 like 2, endophilin A1
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GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Cytosol	Golgi Membrane Early Endosome Cytosol Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane Synaptic Vesicle Membrane Neuronal Cell Body Perinuclear Region Of Cytoplasm Basal Dendrite Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse
	Molecular Function	Translation Repressor Activity, MRNA Regulatory Element Binding Thymidylate Synthase Activity Folic Acid Binding Drug Binding Protein Homodimerization Activity Sequence-specific MRNA Binding	Protein Binding Protein C-terminus Binding Lipid Binding Protein Kinase Binding Identical Protein Binding
	Biological Process	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle DTMP Biosynthetic Process DTTP Biosynthetic Process Aging Circadian Rhythm Response To Toxic Substance Nucleobase-containing Small Molecule Interconversion Negative Regulation Of Translation Modulation By Virus Of Host Process Uracil Metabolic Process Methylation Response To Progesterone Response To Vitamin A Response To Cytokine Tetrahydrofolate Interconversion Response To Drug Response To Ethanol Response To Organophosphorus Developmental Growth Cartilage Development Response To Glucocorticoid Response To Folic Acid Intestinal Epithelial Cell Maturation DNA Biosynthetic Process Liver Regeneration	Negative Regulation Of Protein Phosphorylation Signal Transduction Central Nervous System Development Negative Regulation Of Gene Expression Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Neuron Projection Development Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Synaptic Vesicle Endocytosis Lipid Tube Assembly Membrane Organization Dendrite Extension Membrane Tubulation Membrane Bending Vesicle Scission Positive Regulation Of Membrane Tubulation Negative Regulation Of Blood-brain Barrier Permeability Cellular Response To Brain-derived Neurotrophic Factor Stimulus Regulation Of Clathrin-dependent Endocytosis
Pathways		Interconversion of nucleotide di- and triphosphates G1/S-Specific Transcription	Retrograde neurotrophin signalling Retrograde neurotrophin signalling EGFR downregulation MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Recycling pathway of L1 Recycling pathway of L1 Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell
Drugs		Raltitrexed Floxuridine Trifluridine Gemcitabine Fluorouracil Methotrexate Pemetrexed Capecitabine Thymidine monophosphate 10-Propargyl-5,8-Dideazafolic Acid Deoxyuridine monophosphate S,S-(2-Hydroxyethyl)Thiocysteine Thymectacin ANX-510 OSI-7904L Pralatrexate 2,4-Diamino-5-phenyl-6-ethylpyrimidine N-[2-Chloro-5-(trifluoromethyl)phenyl]imidodicarbonimidic diamide N-(3,5-dimethoxyphenyl)imidodicarbonimidic diamide 6,6-DIMETHYL-1-[3-(2,4,5-TRICHLOROPHENOXY)PROPOXY]-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE Tegafur Tegafur-uracil
Diseases
GWAS		Leukocyte telomere length ( 32109421 31171785) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Testicular germ cell tumor ( 28604728) Urinary metabolite levels in chronic kidney disease ( 31959995)	Cerebral cortical growth ( 29682794) Cognitive performance ( 19734545) FEV1 ( 30804560) Heart failure ( 20445134) Lung function (FVC) ( 30804560) Midgestational circulating levels of PBDEs ( 28235828) Multiple sclerosis ( 19010793) Myopia ( 27182965) Obesity-related traits ( 23251661) Parkinson's disease ( 22451204 32201043 27182965 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Pursuit maintenance gain ( 29064472) Small cell lung carcinoma ( 28604730) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		3 interacting genes: CDC42 SH3GL2 UPF2	51 interacting genes: ACTG1 ADAM15 ADAM19 ADRB1 AMPH APP ARNT2 ATXN2 BIN1 CD2AP CLEC3B DACT1 DLGAP4 DNM1 DNM2 DPPA4 DPYSL4 EGFL6 EMD ERH F13A1 FBXO32 GCH1 GSTM3 HLA-DQA1 IGHM IL6 ITCH ITSN1 LCP2 LRRK2 MAP4K3 MAST2 PAK2 PAXIP1 PDCD6IP PPP1R21 PPP6R1 PRR14 SH3GL3 SH3KBP1 SLC17A7 SYNJ1 TCEA2 TERF1 TIAM2 TMEM108 TYMS ZNF219 ZNF580 ZXDC
Entrez ID		7298	6456
HPRD ID		01774	05125
Ensembl ID		ENSG00000176890	ENSG00000107295
Uniprot IDs		P04818 Q53Y97	Q7Z376 Q99962
PDB IDs		1HVY 1HW3 1HW4 1HZW 1I00 1JU6 1JUJ 1YPV 2ONB 2RD8 2RDA 3EAW 3EBU 3ED7 3EDW 3EF9 3EGY 3EHI 3EJL 3GG5 3GH0 3GH2 3H9K 3HB8 3N5E 3N5G 3OB7 4E28 4FGT 4G2O 4G6W 4GD7 4GYH 4H1I 4JEF 4KPW 4O1U 4O1X 4UP1 5HS3 5WRN 5X4W 5X4X 5X4Y 5X5A 5X5D 5X5Q 5X66 5X67 5X69 6OJU 6OJV 6PF3 6PF4 6PF5 6PF6 6QXG 6QXH 6QYQ 6R2E	1X03 1X04 2D4C 2DBM
Enriched GO Terms of Interacting Partners?
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