SH3GL2 and CLEC3B

Data Source:
BioGRID (two hybrid)

		SH3GL2	CLEC3B
Description		SH3 domain containing GRB2 like 2, endophilin A1	C-type lectin domain family 3 member B
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GO Annotations	Cellular Component	Golgi Membrane Early Endosome Cytosol Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane Synaptic Vesicle Membrane Neuronal Cell Body Perinuclear Region Of Cytoplasm Basal Dendrite Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse	Granular Component Extracellular Region Extracellular Space Cytoplasm Platelet Dense Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Protein Binding Protein C-terminus Binding Lipid Binding Protein Kinase Binding Identical Protein Binding	Calcium Ion Binding Heparin Binding Carbohydrate Binding Kringle Domain Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Signal Transduction Central Nervous System Development Negative Regulation Of Gene Expression Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Neuron Projection Development Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Synaptic Vesicle Endocytosis Lipid Tube Assembly Membrane Organization Dendrite Extension Membrane Tubulation Membrane Bending Vesicle Scission Positive Regulation Of Membrane Tubulation Negative Regulation Of Blood-brain Barrier Permeability Cellular Response To Brain-derived Neurotrophic Factor Stimulus Regulation Of Clathrin-dependent Endocytosis	Ossification Platelet Degranulation Positive Regulation Of Plasminogen Activation Bone Mineralization Cellular Response To Organic Substance Cellular Response To Transforming Growth Factor Beta Stimulus
Pathways		Retrograde neurotrophin signalling Retrograde neurotrophin signalling EGFR downregulation MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Recycling pathway of L1 Recycling pathway of L1 Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell	Platelet degranulation
Drugs			Tenecteplase Lanoteplase Copper
Diseases
GWAS		Cerebral cortical growth ( 29682794) Cognitive performance ( 19734545) FEV1 ( 30804560) Heart failure ( 20445134) Lung function (FVC) ( 30804560) Midgestational circulating levels of PBDEs ( 28235828) Multiple sclerosis ( 19010793) Myopia ( 27182965) Obesity-related traits ( 23251661) Parkinson's disease ( 22451204 32201043 27182965 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Pursuit maintenance gain ( 29064472) Small cell lung carcinoma ( 28604730) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Acne (severe) ( 24927181) Blood protein levels ( 30072576)
Interacting Genes		51 interacting genes: ACTG1 ADAM15 ADAM19 ADRB1 AMPH APP ARNT2 ATXN2 BIN1 CD2AP CLEC3B DACT1 DLGAP4 DNM1 DNM2 DPPA4 DPYSL4 EGFL6 EMD ERH F13A1 FBXO32 GCH1 GSTM3 HLA-DQA1 IGHM IL6 ITCH ITSN1 LCP2 LRRK2 MAP4K3 MAST2 PAK2 PAXIP1 PDCD6IP PPP1R21 PPP6R1 PRR14 SH3GL3 SH3KBP1 SLC17A7 SYNJ1 TCEA2 TERF1 TIAM2 TMEM108 TYMS ZNF219 ZNF580 ZXDC	12 interacting genes: ANXA7 APP CDKN1A GADD45A GSK3B HGF PLAT PLG RPS6KA6 RPS6KB1 SH3GL2 TK1
Entrez ID		6456	7123
HPRD ID		05125	01759
Ensembl ID		ENSG00000107295	ENSG00000163815
Uniprot IDs		Q7Z376 Q99962	E9PHK0 P05452
PDB IDs		1X03 1X04 2D4C 2DBM	1HTN 1RJH 1TN3 3L9J
Enriched GO Terms of Interacting Partners?
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