SH3GL2 and IGHM

Data Source:
BioGRID (two hybrid)

		SH3GL2	IGHM
Description		SH3 domain containing GRB2 like 2, endophilin A1	immunoglobulin heavy constant mu
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Early Endosome Cytosol Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane Synaptic Vesicle Membrane Neuronal Cell Body Perinuclear Region Of Cytoplasm Basal Dendrite Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse	Extracellular Space Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Immunoglobulin Complex, Circulating Extracellular Exosome Pentameric IgM Immunoglobulin Complex Hexameric IgM Immunoglobulin Complex Blood Microparticle
	Molecular Function	Protein Binding Protein C-terminus Binding Lipid Binding Protein Kinase Binding Identical Protein Binding	Single-stranded DNA Binding Antigen Binding Protein Binding Phosphatidylcholine Binding Immunoglobulin Receptor Binding Peptidoglycan Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Signal Transduction Central Nervous System Development Negative Regulation Of Gene Expression Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Neuron Projection Development Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Synaptic Vesicle Endocytosis Lipid Tube Assembly Membrane Organization Dendrite Extension Membrane Tubulation Membrane Bending Vesicle Scission Positive Regulation Of Membrane Tubulation Negative Regulation Of Blood-brain Barrier Permeability Cellular Response To Brain-derived Neurotrophic Factor Stimulus Regulation Of Clathrin-dependent Endocytosis	Adaptive Immune Response Phagocytosis, Recognition Phagocytosis, Engulfment Complement Activation, Classical Pathway Antibacterial Humoral Response Defense Response To Bacterium Innate Immune Response Defense Response To Gram-negative Bacterium B Cell Receptor Signaling Pathway Positive Regulation Of B Cell Activation Leukocyte Migration
Pathways		Retrograde neurotrophin signalling Retrograde neurotrophin signalling EGFR downregulation MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Recycling pathway of L1 Recycling pathway of L1 Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell
Drugs
Diseases
GWAS		Cerebral cortical growth ( 29682794) Cognitive performance ( 19734545) FEV1 ( 30804560) Heart failure ( 20445134) Lung function (FVC) ( 30804560) Midgestational circulating levels of PBDEs ( 28235828) Multiple sclerosis ( 19010793) Myopia ( 27182965) Obesity-related traits ( 23251661) Parkinson's disease ( 22451204 32201043 27182965 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Pursuit maintenance gain ( 29064472) Small cell lung carcinoma ( 28604730) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		51 interacting genes: ACTG1 ADAM15 ADAM19 ADRB1 AMPH APP ARNT2 ATXN2 BIN1 CD2AP CLEC3B DACT1 DLGAP4 DNM1 DNM2 DPPA4 DPYSL4 EGFL6 EMD ERH F13A1 FBXO32 GCH1 GSTM3 HLA-DQA1 IGHM IL6 ITCH ITSN1 LCP2 LRRK2 MAP4K3 MAST2 PAK2 PAXIP1 PDCD6IP PPP1R21 PPP6R1 PRR14 SH3GL3 SH3KBP1 SLC17A7 SYNJ1 TCEA2 TERF1 TIAM2 TMEM108 TYMS ZNF219 ZNF580 ZXDC	19 interacting genes: APP CD22 CD79A CEP72 GADD45A GSK3B HPR HSPA5 JCHAIN MAP3K20 MAPKAPK3 PTK2 SH3GL2 SMN1 TK1 UBQLN4 UFD1 VPREB1 VPREB3
Entrez ID		6456	3507
HPRD ID		05125	00912
Ensembl ID		ENSG00000107295	ENSG00000211899
Uniprot IDs		Q7Z376 Q99962
PDB IDs		1X03 1X04 2D4C 2DBM
Enriched GO Terms of Interacting Partners?
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