TTPA and MMS22L

Data Source:
BioGRID (affinity chromatography technology)

		TTPA	MMS22L
Description		alpha tocopherol transfer protein	MMS22 like, DNA repair protein
Image			No pdb structure
GO Annotations	Cellular Component	Late Endosome Cytosol	Nucleoplasm Cytosol FACT Complex MCM Complex Nuclear Replication Fork
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Vitamin E Binding Phosphatidylinositol-3,4-bisphosphate Binding Lipid Transfer Activity Phosphatidylinositol Bisphosphate Binding	Protein Binding
	Biological Process	Lipid Metabolic Process Response To Nutrient Response To PH Developmental Process Vitamin E Metabolic Process Vitamin Transport Intracellular PH Reduction Negative Regulation Of Cell Death Intermembrane Lipid Transfer	Double-strand Break Repair Via Homologous Recombination Replication Fork Processing
Pathways		Vitamin E
Drugs
Diseases		Ataxia with isolated vitamin E deficiency (AVED); Friedreich-like ataxia
GWAS			Adult body size ( 32376654) Automobile speeding propensity ( 30643258) Body mass index ( 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Chronotype ( 30696823) Gut microbiota (bacterial taxa) ( 27694959) Hand grip strength ( 29691431) Morning person ( 30696823) Multiple sclerosis (OCB status) ( 23785401) Number of sexual partners ( 30643258) Photic sneeze reflex ( 27182965) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245)
Interacting Genes		46 interacting genes: AGTRAP APOA5 APOC2 APP ARFIP2 ARMC12 BIRC7 CISD2 CMTM4 CMTM5 COQ3 CYSRT1 DGAT2L6 DHODH FADS6 FAM114A2 FAM25A FAM25C FAM25G FGF14 FKBP7 GOLGA2 HSD17B11 JOSD2 KRTAP10-7 KRTAP12-2 KRTAP12-3 KRTAP2-3 KRTAP2-4 LEUTX MAL2 MRM1 NBPF19 NDUFA7 NOTCH2NLA PEX12 REEP2 RPRM SAR1A SCAMP1 SCAMP5 SDR16C5 SLC35E3 SYNGR3 THAP4 TPD52	4 interacting genes: ESCO2 FBXW7 RAD51 RPA1
Entrez ID		7274	253714
HPRD ID		02685	12865
Ensembl ID		ENSG00000137561	ENSG00000146263
Uniprot IDs		P49638	Q6ZRQ5
PDB IDs		1OIP 1OIZ 1R5L 5MUE 5MUG
Enriched GO Terms of Interacting Partners?
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