TTN and AMOT

Data Source:
BioGRID (two hybrid)

		TTN	AMOT
Description		titin	angiomotin
Image
GO Annotations	Cellular Component	Condensed Nuclear Chromosome Extracellular Region Cytosol Z Disc I Band Extracellular Exosome	Ruffle Nucleoplasm Cytosol Actin Filament Plasma Membrane Bicellular Tight Junction COP9 Signalosome External Side Of Plasma Membrane Lamellipodium Cell Junction Endocytic Vesicle Cytoplasmic Vesicle
	Molecular Function	Protease Binding Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Calcium Ion Binding Protein Binding Calmodulin Binding ATP Binding Structural Constituent Of Muscle Enzyme Binding Protein Kinase Binding Telethonin Binding Identical Protein Binding Actinin Binding Protein Self-association Actin Filament Binding Muscle Alpha-actinin Binding Structural Molecule Activity Conferring Elasticity Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Binding Signaling Receptor Activity Angiostatin Binding
	Biological Process	Platelet Degranulation Cardiac Muscle Hypertrophy Muscle Contraction Striated Muscle Contraction Mitotic Chromosome Condensation Positive Regulation Of Gene Expression Protein Kinase A Signaling Peptidyl-tyrosine Phosphorylation Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Skeletal Muscle Myosin Thick Filament Assembly Detection Of Muscle Stretch Sarcomere Organization Regulation Of Protein Kinase Activity Cardiac Muscle Fiber Development Sarcomerogenesis Positive Regulation Of Protein Secretion Regulation Of Catalytic Activity Response To Calcium Ion Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction	Angiogenesis Vasculogenesis In Utero Embryonic Development Gastrulation With Mouth Forming Second Establishment Of Cell Polarity Involved In Ameboidal Cell Migration Chemotaxis Negative Regulation Of Angiogenesis Actin Cytoskeleton Organization Regulation Of Cell Migration Negative Regulation Of GTPase Activity Cellular Protein Localization Hippo Signaling Positive Regulation Of Embryonic Development Cell Migration Involved In Gastrulation Blood Vessel Endothelial Cell Migration Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Platelet degranulation Striated Muscle Contraction
Drugs
Diseases		Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Hypertrophic cardiomyopathy (HCM) Dilated cardiomyopathy (DCM)
GWAS		Atrial fibrillation ( 29290336 30061737 29892015) Bone mineral density (hip) ( 30172743) Breast size ( 22747683) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 32602732) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Left ventricular ejection fraction ( 32382064) Left ventricular end-diastolic volume ( 32382064) Left ventricular end-systolic volume ( 32382064) PR interval ( 30046033 32439900) QT interval ( 20031603 29213071 24952745 29874175) Rapid functional decline in sporadic amyotrophic lateral sclerosis ( 26746183) Refractive error ( 32231278) Resting heart rate ( 27798624) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971)
Interacting Genes		76 interacting genes: ABLIM1 ABLIM2 ACTA1 ACTN1 ACTN2 ACTN3 ACTN4 AMOT ANK1 ANKRD1 ANKRD2 ANKRD23 ANKRD28 ASH2L ATP5F1D C1QTNF9 CALM1 CAPN3 CCT6A CHD4 CLIP4 CRYAB DNAJB5 DNAJB6 ENO1 ENO3 EXOSC10 FHL1 FHL2 FLNA FN1 FNDC3B GABARAP HSPA1B HSPB2 ITGB1BP2 ITGB5 JPH1 LIMS1 MAPK1 MAST2 MYBPC1 MYBPC2 MYBPC3 MYBPH MYCBP2 MYH9 MYOM1 MYOM2 MYPN NBR1 NEB NEK9 NEO1 OBSCN PARD3 PHGDH POMP PYGM RNF167 RPL12 RYR1 SF1 SGCG SH3GLB1 SQSTM1 SRPK2 TAB2 TCAP TRIM55 TRIM63 TSC22D2 TTC3 UBE2I UGP2 VAV2	60 interacting genes: ACTA1 AMOTL2 AP1M1 APP AQP1 AXIN2 C1orf216 CAPN3 DISC1 FHL2 HOXA1 HPCAL1 KIAA1328 KRT14 KRT15 KRT16 KRT19 KRT24 KRT27 KRT31 KRT34 KRT36 KRT75 LCE1D LMNB2 LMO4 LURAP1 LZTS1 MAGEA4 MAGI1 MAPK3 MED4 MEOX2 MIS18A MYBPC1 MYBPC2 MYOM3 NEDD4 NEDD4L NF2 NTAQ1 NUFIP2 PBLD PIBF1 PIK3C2A PIN1 PLG PRKAA2 PTEN PTPA PTPN14 RBM48 SEPTIN1 SLIRP SMC1A SNAPC5 SOCS6 THRA TTN UNC119
Entrez ID		7273	154796
HPRD ID		01787	02327
Ensembl ID		ENSG00000155657	ENSG00000126016
Uniprot IDs		A0A0A0MRA3 A0A0A0MTS7 Q7Z3B7 Q8WZ42	Q4VCS5
PDB IDs		1BPV 1G1C 1NCT 1NCU 1TIT 1TIU 1TKI 1TNM 1TNN 1WAA 1YA5 2A38 2BK8 2F8V 2ILL 2J8H 2J8O 2NZI 2RQ8 2WP3 2WWK 2WWM 2Y9R 3B43 3KNB 3LCY 3LPW 3PUC 3Q5O 3QP3 4C4K 4JNW 4O00 4QEG 4UOW 5BS0 5JDD 5JDE 5JDJ 5JOE 6DL4 6H4L 6HCI 6I0Y 6SDB	6JJX
Enriched GO Terms of Interacting Partners?
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