NR2C1 and NR2C2

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vivo, in vitro)

		NR2C1	NR2C2
Description		nuclear receptor subfamily 2 group C member 1	nuclear receptor subfamily 2 group C member 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleoplasm PML Body	Chromatin Nucleoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Steroid Hormone Receptor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Signaling Receptor Activity Protein Homodimerization Activity Histone Deacetylase Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Cell Differentiation Intracellular Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Anatomical Structure Development	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Spermatogenesis Nervous System Development Cell Differentiation Intracellular Receptor Signaling Pathway Positive Regulation Of Embryonic Development Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Development
Pathways		Nuclear Receptor transcription pathway SUMOylation of intracellular receptors	Nuclear Receptor transcription pathway
Drugs
Diseases
GWAS		Body fat mass ( 28552196) Chromosomal aberration frequency (chromosome type) ( 31586183) Coronary artery disease ( 32469254) Intracranial aneurysm ( 33199917) Trunk fat mass ( 28552196)	Alcohol and nicotine co-dependence ( 22488850)
Interacting Genes		8 interacting genes: AR ESR1 HDAC3 HDAC4 NR2C2 NRIP1 NUDT3 RARA	23 interacting genes: AR CD2AP CDC37 CHUK ESR1 FKBP5 HDAC4 HNF4A HSP90AA1 HSP90AB1 IKBKB ITSN2 JAZF1 KDM1A NR2C1 NR2C2AP PEBP1 RAC1 RXRB TAB1 TAB2 TRAF2 TRIM55
Entrez ID		7181	7182
HPRD ID		03318	03253
Ensembl ID		ENSG00000120798	ENSG00000177463
Uniprot IDs		H9NIM2 H9NIM3 P13056	F2YGU2 P49116
PDB IDs			3P0U
Enriched GO Terms of Interacting Partners?
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