NR2C2 and JAZF1

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		NR2C2	JAZF1
Description		nuclear receptor subfamily 2 group C member 2	JAZF zinc finger 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleoplasm	Fibrillar Center Nucleus Nucleoplasm Cytosol Transcription Repressor Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Transcription Corepressor Activity Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Spermatogenesis Nervous System Development Cell Differentiation Intracellular Receptor Signaling Pathway Positive Regulation Of Embryonic Development Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Development	Negative Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process
Pathways		Nuclear Receptor transcription pathway
Drugs
Diseases			Type II diabetes mellitus
GWAS		Alcohol and nicotine co-dependence ( 22488850)	Alanine transaminase levels ( 29403010) Alcoholic chronic pancreatitis ( 28754779) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Asthma ( 31361310 31959851 30929738 32296059 31619474) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Blond vs. brown/black hair color ( 30531825) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 23128233) Eosinophilic esophagitis ( 29904099) FEV1 ( 30804560) Free thyroxine concentration ( 24722205) Gout ( 22179738) Heel bone mineral density ( 30598549 28869591) Height ( 28552196 20881960 25282103 19343178 23563607 18952825) Hip circumference adjusted for BMI ( 25673412) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Lung function (FVC) ( 30804560) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Medication use (drugs used in diabetes) ( 31015401) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Moyamoya disease ( 29273593) Multiple sclerosis ( 31604244 24076602) Neutrophil percentage of white cells ( 32888494) Peak expiratory flow ( 30804560) Prostate cancer ( 18264096 31562322) Prostate-specific antigen levels ( 28139693) Rheumatoid arthritis ( 30423114 24390342) Systemic lupus erythematosus ( 26606652 26502338 28714469 19838195) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systolic blood pressure ( 30224653 30578418) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Total body bone mineral density ( 29304378) Triglyceride levels ( 32203549) Type 2 diabetes ( 27189021 22885922 18372903 24509480 30054458 26961502 29358691 30297969 31118516 32499647 20581827 28869590) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28552196 25673412 28448500) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		23 interacting genes: AR CD2AP CDC37 CHUK ESR1 FKBP5 HDAC4 HNF4A HSP90AA1 HSP90AB1 IKBKB ITSN2 JAZF1 KDM1A NR2C1 NR2C2AP PEBP1 RAC1 RXRB TAB1 TAB2 TRAF2 TRIM55	4 interacting genes: FAM9B NR2C2 PPARG RXRA
Entrez ID		7182	221895
HPRD ID		03253	09373
Ensembl ID		ENSG00000177463	ENSG00000153814
Uniprot IDs		F2YGU2 P49116	Q86VZ6
PDB IDs		3P0U
Enriched GO Terms of Interacting Partners?
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