TPR and NUP98

Data Source:
HPRD (in vivo)

		TPR	NUP98
Description		translocated promoter region, nuclear basket protein	nucleoporin 98 and 96 precursor
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GO Annotations	Cellular Component	Kinetochore Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Cytoplasmic Dynein Complex Extrinsic Component Of Membrane Nuclear Membrane Nuclear Periphery Nuclear Inclusion Body Host Cell Nuclear Pore Nuclear Basket Mitotic Spindle	Kinetochore Nuclear Envelope Nuclear Pore Nucleoplasm Cytosol Nuclear Body Nuclear Pore Outer Ring Nuclear Membrane Nuclear Periphery Nuclear Inclusion Body Intracellular Membrane-bounded Organelle Host Cell Nuclear Pore Nuclear Basket Ribonucleoprotein Complex
	Molecular Function	Chromatin Binding RNA Binding MRNA Binding Protein Binding Tubulin Binding Structural Constituent Of Nuclear Pore Heat Shock Protein Binding Protein Homodimerization Activity Protein-membrane Adaptor Activity Mitogen-activated Protein Kinase Binding Dynein Complex Binding	Transcription Coactivator Activity MRNA Binding Transporter Activity Protein Binding Nuclear Localization Sequence Binding Serine-type Peptidase Activity Structural Constituent Of Nuclear Pore Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Glycolytic Process RNA Import Into Nucleus RNA Export From Nucleus MRNA Export From Nucleus TRNA Export From Nucleus Protein Import Into Nucleus Protein Export From Nucleus Nuclear Pore Organization Mitotic Spindle Assembly Checkpoint Regulation Of MRNA Export From Nucleus Regulation Of Mitotic Sister Chromatid Separation Viral Process Protein Sumoylation Viral Transcription Positive Regulation Of Heterochromatin Assembly Regulation Of Protein Stability MRNA Export From Nucleus In Response To Heat Stress Regulation Of Protein Localization Cellular Response To Heat Cellular Response To Interferon-alpha Regulation Of Protein Import Into Nucleus Positive Regulation Of Protein Import Into Nucleus Nuclear Matrix Organization Negative Regulation Of Translational Initiation Regulation Of Protein Export From Nucleus Positive Regulation Of Protein Export From Nucleus Negative Regulation Of RNA Export From Nucleus Nuclear Pore Complex Assembly Cell Division Regulation Of Gene Silencing By MiRNA Response To Epidermal Growth Factor Intracellular Transport Of Virus Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Intracellular Protein Transport Regulation Of Cellular Response To Heat Regulation Of Mitotic Spindle Assembly	Regulation Of Glycolytic Process MRNA Export From Nucleus TRNA Export From Nucleus Proteolysis Protein Import Into Nucleus Nucleocytoplasmic Transport Nuclear Pore Organization Viral Process Protein Sumoylation Viral Transcription Positive Regulation Of Transcription, DNA-templated Positive Regulation Of MRNA Splicing, Via Spliceosome Nuclear Pore Complex Assembly Regulation Of Gene Silencing By MiRNA Intracellular Transport Of Virus Regulation Of Cellular Response To Heat
Pathways		ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events
Drugs
Diseases		Thyroid cancer
GWAS			Malaria ( 31844061) Metabolite levels (Dihydroxy docosatrienoic acid) ( 23934736)
Interacting Genes		13 interacting genes: APC ERCC6 HTT IFI16 MAD1L1 MAP3K4 MAPK1 MDM2 NUP153 NUP98 SHC1 SUMO2 YWHAQ	19 interacting genes: APC CREBBP CSNK2A1 EP300 HDAC1 IPO5 KPNB1 NFX1 NUP133 NUP155 NUP62 NUP88 NXF1 RAE1 RCC1 SEC13 TNPO1 TNPO2 TPR
Entrez ID		7175	4928
HPRD ID		08927	03012
Ensembl ID		ENSG00000047410	ENSG00000110713
Uniprot IDs		P12270	P52948
PDB IDs		5TO5 5TO6 5TO7 5TVB	1KO6 2Q5X 2Q5Y 3MMY 4OWR 5A9Q 6BZM
Enriched GO Terms of Interacting Partners?
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