TPR and IFI16

Data Source:
HPRD (in vivo, two hybrid)

		TPR	IFI16
Description		translocated promoter region, nuclear basket protein	interferon gamma inducible protein 16
Image
GO Annotations	Cellular Component	Kinetochore Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Cytoplasmic Dynein Complex Extrinsic Component Of Membrane Nuclear Membrane Nuclear Periphery Nuclear Inclusion Body Host Cell Nuclear Pore Nuclear Basket Mitotic Spindle	Nucleus Nucleoplasm Nucleolus Cytosol Membrane Nuclear Speck
	Molecular Function	Chromatin Binding RNA Binding MRNA Binding Protein Binding Tubulin Binding Structural Constituent Of Nuclear Pore Heat Shock Protein Binding Protein Homodimerization Activity Protein-membrane Adaptor Activity Mitogen-activated Protein Kinase Binding Dynein Complex Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Double-stranded DNA Binding RNA Binding Protein Binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Glycolytic Process RNA Import Into Nucleus RNA Export From Nucleus MRNA Export From Nucleus TRNA Export From Nucleus Protein Import Into Nucleus Protein Export From Nucleus Nuclear Pore Organization Mitotic Spindle Assembly Checkpoint Regulation Of MRNA Export From Nucleus Regulation Of Mitotic Sister Chromatid Separation Viral Process Protein Sumoylation Viral Transcription Positive Regulation Of Heterochromatin Assembly Regulation Of Protein Stability MRNA Export From Nucleus In Response To Heat Stress Regulation Of Protein Localization Cellular Response To Heat Cellular Response To Interferon-alpha Regulation Of Protein Import Into Nucleus Positive Regulation Of Protein Import Into Nucleus Nuclear Matrix Organization Negative Regulation Of Translational Initiation Regulation Of Protein Export From Nucleus Positive Regulation Of Protein Export From Nucleus Negative Regulation Of RNA Export From Nucleus Nuclear Pore Complex Assembly Cell Division Regulation Of Gene Silencing By MiRNA Response To Epidermal Growth Factor Intracellular Transport Of Virus Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Intracellular Protein Transport Regulation Of Cellular Response To Heat Regulation Of Mitotic Spindle Assembly	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cytokine Production Activation Of Innate Immune Response Autophagy Inflammatory Response Regulation Of Autophagy Myeloid Cell Differentiation Monocyte Differentiation Positive Regulation Of Type I Interferon Production Positive Regulation Of Interleukin-1 Beta Production Cellular Response To Interferon-beta Regulation Of Gene Expression, Epigenetic Cellular Response To Glucose Starvation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of DNA Binding Negative Regulation Of Viral Genome Replication Innate Immune Response Negative Regulation Of Innate Immune Response Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Cellular Response To Ionizing Radiation Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Activation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Cysteine-type Endopeptidase Activity
Pathways		ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events	STING mediated induction of host immune responses IRF3-mediated induction of type I IFN
Drugs
Diseases		Thyroid cancer
GWAS			Blood protein levels ( 29875488) C-reactive protein ( 22939635) Celiac disease or Rheumatoid arthritis ( 21383967) Lymphocyte percentage of white cells ( 32888494) Neutrophil count in HIV-infection ( 25884002) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Periodontal disease-related phenotype (Socransky) ( 26962152)
Interacting Genes		13 interacting genes: APC ERCC6 HTT IFI16 MAD1L1 MAP3K4 MAPK1 MDM2 NUP153 NUP98 SHC1 SUMO2 YWHAQ	11 interacting genes: APP AR AURKA BRCA1 CSNK2A1 ID1 ID2 ID3 TP53 TP53BP1 TPR
Entrez ID		7175	3428
HPRD ID		08927	00969
Ensembl ID		ENSG00000047410	ENSG00000163565
Uniprot IDs		P12270	Q16666
PDB IDs		5TO5 5TO6 5TO7 5TVB	2OQ0 3B6Y 3RLN 3RLO 3RNU 4QGU
Enriched GO Terms of Interacting Partners?
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