APCS and GK

Data Source:
BioGRID (two hybrid)

		APCS	GK
Description		amyloid P component, serum	glycerol kinase
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Mitochondrion Mitochondrial Outer Membrane Cytosol Extracellular Exosome
	Molecular Function	Complement Component C1q Complex Binding Calcium Ion Binding Protein Binding Low-density Lipoprotein Particle Binding Carbohydrate Binding Identical Protein Binding Virion Binding Unfolded Protein Binding	Glycerol Kinase Activity Protein Binding ATP Binding Phosphotransferase Activity, Alcohol Group As Acceptor
	Biological Process	Negative Regulation Of Acute Inflammatory Response Protein Folding Acute-phase Response Complement Activation, Classical Pathway Cellular Protein Metabolic Process Negative Regulation By Host Of Viral Process Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Innate Immune Response Negative Regulation Of Monocyte Differentiation Negative Regulation Of Viral Entry Into Host Cell Negative Regulation Of Viral Process Chaperone-mediated Protein Complex Assembly Negative Regulation Of Wound Healing Negative Regulation Of Exo-alpha-sialidase Activity Negative Regulation Of Glycoprotein Metabolic Process	Glycerol Metabolic Process Triglyceride Metabolic Process Phosphorylation Triglyceride Biosynthetic Process Glycerol Catabolic Process Glycerol-3-phosphate Biosynthetic Process
Pathways		Amyloid fiber formation	Triglyceride biosynthesis
Drugs		Zinc Methyl 4,6-O-[(1R)-1-carboxyethylidene]-beta-D-galactopyranoside Bis-1,2-{[(Z)-2-carboxy-2-methyl-1,3-dioxane]-5-yloxycarbamoyl}-ethane BIS-1,2-{[(Z)-2CARBOXY-2-METHYL-1,3-DIOXANE]-5-YLOXYCARBONYL}-PIPERAZINE Copper Zinc acetate
Diseases			Glycerol kinase deficiency (GKD), including: Hyperglycerolemia; Chromosome Xp21 deletion syndrome; Adrenal hypoplasia, congenital (AHC); Duchenne muscular dystrophy (DMD)
GWAS		Blood protein levels ( 30072576 29875488 28240269) C-reactive protein ( 22939635)	Cardiovascular risk factors (age interaction) ( 20838585)
Interacting Genes		18 interacting genes: ALX1 C1QA C4BPA CALU COL4A1 COPS5 CRP FCGR1A FCGR2B FCGR3A FCGR3B FN1 GK GOT2 GRB2 HES1 LAMA1 TG	11 interacting genes: AOX1 APCS CLPTM1L CYP3A4 EIF4G1 FBXO28 GPD1 IPO13 NR4A1 OPLAH RXRA
Entrez ID		325	2710
HPRD ID		00101	08363
Ensembl ID		ENSG00000132703	ENSG00000198814
Uniprot IDs		P02743 V9HWP0	B4DH54 P32189
PDB IDs		1GYK 1LGN 1SAC 2A3W 2A3X 2A3Y 2W08 3D5O 3KQR 4AVS 4AVT 4AVV 4AYU
Enriched GO Terms of Interacting Partners?
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