TGIF1 and IRF2BP1

Data Source:
HPRD (in vivo, two hybrid)

		TGIF1	IRF2BP1
Description		TGFB induced factor homeobox 1	interferon regulatory factor 2 binding protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleoplasm	Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Co-SMAD Binding Sequence-specific Double-stranded DNA Binding	Transcription Corepressor Activity Protein Binding Transcription Factor Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Response To Drug Cellular Response To Growth Factor Stimulus	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Regulation Of Transcription By RNA Polymerase II
Pathways		Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Drugs
Diseases		Holoprosencephaly (HPE)
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Periodontitis (DPAL) ( 24024966) Response to methotrexate in juvenile idiopathic arthritis ( 24709693)	Apolipoprotein A1 levels ( 32203549) Asthma ( 31959851) Gallstone disease ( 30504769) HDL cholesterol levels ( 32203549) Mean corpuscular hemoglobin ( 32888494)
Interacting Genes		21 interacting genes: A2M APP AR CTBP1 CTBP2 EEF1A1 HDAC1 HMGB1 IRF2BP1 JUN LRIF1 MAPK1 MAPK3 MDFI MED31 MOB3A PML SIN3A SMAD2 SMAD3 WWP1	8 interacting genes: ATF2 IRF2 IRF9 JDP2 PCBD2 SMAD1 TGIF1 UBE2L3
Entrez ID		7050	26145
HPRD ID		04023	17159
Ensembl ID		ENSG00000177426	ENSG00000170604
Uniprot IDs		Q15583	Q8IU81
PDB IDs		2LK2 6FQP 6FQQ
Enriched GO Terms of Interacting Partners?
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