IRF2BP1 and TGIF1

Data Source:
HPRD (in vivo, two hybrid)

		IRF2BP1	TGIF1
Description		interferon regulatory factor 2 binding protein 1	TGFB induced factor homeobox 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Chromatin Nucleoplasm
	Molecular Function	Transcription Corepressor Activity Protein Binding Transcription Factor Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Co-SMAD Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Response To Drug Cellular Response To Growth Factor Stimulus
Pathways			Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Drugs
Diseases			Holoprosencephaly (HPE)
GWAS		Apolipoprotein A1 levels ( 32203549) Asthma ( 31959851) Gallstone disease ( 30504769) HDL cholesterol levels ( 32203549) Mean corpuscular hemoglobin ( 32888494)	Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Periodontitis (DPAL) ( 24024966) Response to methotrexate in juvenile idiopathic arthritis ( 24709693)
Interacting Genes		8 interacting genes: ATF2 IRF2 IRF9 JDP2 PCBD2 SMAD1 TGIF1 UBE2L3	21 interacting genes: A2M APP AR CTBP1 CTBP2 EEF1A1 HDAC1 HMGB1 IRF2BP1 JUN LRIF1 MAPK1 MAPK3 MDFI MED31 MOB3A PML SIN3A SMAD2 SMAD3 WWP1
Entrez ID		26145	7050
HPRD ID		17159	04023
Ensembl ID		ENSG00000170604	ENSG00000177426
Uniprot IDs		Q8IU81	Q15583
PDB IDs			2LK2 6FQP 6FQQ
Enriched GO Terms of Interacting Partners?
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