TGIF1 and MOB3A

Data Source:
BioGRID (two hybrid)

		TGIF1	MOB3A
Description		TGFB induced factor homeobox 1	MOB kinase activator 3A
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Co-SMAD Binding Sequence-specific Double-stranded DNA Binding	Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Response To Drug Cellular Response To Growth Factor Stimulus
Pathways		Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Drugs
Diseases		Holoprosencephaly (HPE)
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Periodontitis (DPAL) ( 24024966) Response to methotrexate in juvenile idiopathic arthritis ( 24709693)
Interacting Genes		21 interacting genes: A2M APP AR CTBP1 CTBP2 EEF1A1 HDAC1 HMGB1 IRF2BP1 JUN LRIF1 MAPK1 MAPK3 MDFI MED31 MOB3A PML SIN3A SMAD2 SMAD3 WWP1	7 interacting genes: APP FBXO7 LATS1 LATS2 NEDD4 NEDD4L TGIF1
Entrez ID		7050	126308
HPRD ID		04023	17583
Ensembl ID		ENSG00000177426	ENSG00000172081
Uniprot IDs		Q15583	Q96BX8
PDB IDs		2LK2 6FQP 6FQQ
Enriched GO Terms of Interacting Partners?
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