TCOF1 and NOP56

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro)

		TCOF1	NOP56
Description		treacle ribosome biogenesis factor 1	NOP56 ribonucleoprotein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Nucleolus Cytosol	Fibrillar Center Nucleoplasm Nucleolus Sno(s)RNA-containing Ribonucleoprotein Complex Cytoplasm Membrane Box C/D RNP Complex Small-subunit Processome Pre-snoRNP Complex
	Molecular Function	RNA Binding Transporter Activity Protein Binding Protein-macromolecule Adaptor Activity Protein Heterodimerization Activity Scaffold Protein Binding	RNA Binding Protein Binding SnoRNA Binding Cadherin Binding Histone Methyltransferase Binding
	Biological Process	Skeletal System Development Regulation Of Translation Neural Crest Formation Neural Crest Cell Development Nucleolar Large RRNA Transcription By RNA Polymerase I	RRNA Processing
Pathways			Association of TriC/CCT with target proteins during biosynthesis rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases		Treacher Collins syndrome	Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)
Interacting Genes		9 interacting genes: CSNK2A1 CSNK2A2 NOP56 PCNA SPOP SRPK2 TM9SF1 UBC UBTF	8 interacting genes: BMPR2 CSNK2A1 DYNC1LI1 KLF6 PTEN SDCBP2 TCOF1 UBE2I
Entrez ID		6949	10528
HPRD ID		06026	10119
Ensembl ID		ENSG00000070814	ENSG00000101361
Uniprot IDs		B4DRA2 E7ETY2 H0Y8Y7 Q13428	O00567
PDB IDs
Enriched GO Terms of Interacting Partners?
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