MLX and MLXIPL

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		MLX	MLXIPL
Description		MAX dimerization protein MLX	MLX interacting protein like
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Membrane	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Homodimerization Activity Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Factor Binding Carbohydrate Response Element Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Glucose Mediated Signaling Pathway Negative Regulation Of Peptidyl-serine Phosphorylation Intracellular Signal Transduction Glucose Homeostasis Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Glycolytic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Lipid Biosynthetic Process Fatty Acid Homeostasis Triglyceride Homeostasis Negative Regulation Of Cell Cycle Arrest Negative Regulation Of Oxidative Phosphorylation Energy Homeostasis
Pathways		ChREBP activates metabolic gene expression ChREBP activates metabolic gene expression	PKA-mediated phosphorylation of key metabolic factors PKA-mediated phosphorylation of key metabolic factors AMPK inhibits chREBP transcriptional activation activity ChREBP activates metabolic gene expression ChREBP activates metabolic gene expression PP2A-mediated dephosphorylation of key metabolic factors
Drugs
Diseases
GWAS		Crohn's disease ( 21102463) Type 2 diabetes ( 30297969 29632382 30718926) Type 2 diabetes (time to event) ( 32589924)	Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Apolipoprotein B levels ( 32203549) Birth weight ( 31043758 27680694) Bitter alcoholic beverage consumption ( 31046077) Bitter non-alcoholic beverage consumption ( 31046077) Coffee consumption ( 31959922 31046077) Coffee consumption (cups per day) ( 31837886 25288136) Eosinophil percentage of white cells ( 32888494) Factor VII activity ( 30642921) Gamma glutamyl transferase levels ( 29403010) HDL cholesterol ( 24097068 30275531 20686565) HDL cholesterol levels ( 32203549 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Hypertriglyceridemia ( 27599772 23505323 20657596) Immature fraction of reticulocytes ( 32888494) Lamb consumption ( 32066663) Lipid metabolism phenotypes ( 22286219) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Low density lipoprotein cholesterol levels ( 32154731) Malaria ( 31844061) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Meat-related diet ( 32066663) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 22399527) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Non-oily fish consumption ( 32066663) Platelet count ( 27863252) Platelet distribution width ( 32888494) Postprandial triglyceride levels ( 32603185) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Serum albumin level ( 29403010) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Serum uric acid levels ( 30993211 29403010) Total cholesterol levels ( 30275531) Total triglycerides levels ( 26690388) Triglyceride levels ( 28334899 31087446 32154731 29403010 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 24097068 21909109 18193043 18193044 18193046 20864672 26160806 19060906 19060911 30275531 25961943 20686565 26582766) Urate levels ( 31578528 23263486) Urinary sodium excretion ( 31409800) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) White blood cell count ( 32888494)
Interacting Genes		31 interacting genes: APP BACH2 BEND7 CASK CCT6A DDIT4L GABARAPL1 GABARAPL2 ID3 KRTAP13-3 LNX1 LNX2 MAD1L1 MEI4 MEOX1 MEOX2 MLXIP MLXIPL MNT MXD1 MXD4 PIAS2 RBM39 RHBDD2 SAP30BP TEPSIN TLE5 TNNT2 UBE2I ZBTB32 ZNF620	3 interacting genes: GRB2 MLX NIF3L1
Entrez ID		6945	51085
HPRD ID		04278	12033
Ensembl ID		ENSG00000108788	ENSG00000009950
Uniprot IDs		Q9UH92	Q9NP71
PDB IDs			6MJL 6YGJ
Enriched GO Terms of Interacting Partners?
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