MLXIPL and NIF3L1

Data Source:
HPRD (in vivo, two hybrid)

		MLXIPL	NIF3L1
Description		MLX interacting protein like	NGG1 interacting factor 3 like 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol	Nucleus Cytoplasm Mitochondrion
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Factor Binding Carbohydrate Response Element Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Protein Binding Transcription Factor Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Glucose Mediated Signaling Pathway Negative Regulation Of Peptidyl-serine Phosphorylation Intracellular Signal Transduction Glucose Homeostasis Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Glycolytic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Lipid Biosynthetic Process Fatty Acid Homeostasis Triglyceride Homeostasis Negative Regulation Of Cell Cycle Arrest Negative Regulation Of Oxidative Phosphorylation Energy Homeostasis	Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription
Pathways		PKA-mediated phosphorylation of key metabolic factors PKA-mediated phosphorylation of key metabolic factors AMPK inhibits chREBP transcriptional activation activity ChREBP activates metabolic gene expression ChREBP activates metabolic gene expression PP2A-mediated dephosphorylation of key metabolic factors
Drugs
Diseases
GWAS		Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Apolipoprotein B levels ( 32203549) Birth weight ( 31043758 27680694) Bitter alcoholic beverage consumption ( 31046077) Bitter non-alcoholic beverage consumption ( 31046077) Coffee consumption ( 31959922 31046077) Coffee consumption (cups per day) ( 31837886 25288136) Eosinophil percentage of white cells ( 32888494) Factor VII activity ( 30642921) Gamma glutamyl transferase levels ( 29403010) HDL cholesterol ( 24097068 30275531 20686565) HDL cholesterol levels ( 32203549 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Hypertriglyceridemia ( 27599772 23505323 20657596) Immature fraction of reticulocytes ( 32888494) Lamb consumption ( 32066663) Lipid metabolism phenotypes ( 22286219) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Low density lipoprotein cholesterol levels ( 32154731) Malaria ( 31844061) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Meat-related diet ( 32066663) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 22399527) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Non-oily fish consumption ( 32066663) Platelet count ( 27863252) Platelet distribution width ( 32888494) Postprandial triglyceride levels ( 32603185) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Serum albumin level ( 29403010) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Serum uric acid levels ( 30993211 29403010) Total cholesterol levels ( 30275531) Total triglycerides levels ( 26690388) Triglyceride levels ( 28334899 31087446 32154731 29403010 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 24097068 21909109 18193043 18193044 18193046 20864672 26160806 19060906 19060911 30275531 25961943 20686565 26582766) Urate levels ( 31578528 23263486) Urinary sodium excretion ( 31409800) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) White blood cell count ( 32888494)	Triptolide cytotoxicity ( 26121980)
Interacting Genes		3 interacting genes: GRB2 MLX NIF3L1	93 interacting genes: ALKBH4 AP5B1 APIP ARPIN BDKRB2 BEND7 C14orf119 CASP7 CCDC102B CCDC85B CDKN2B CDKN2C CDKN2D COIL COPS2 CUTC CYRIB DCDC2 DCTD DCTPP1 DHPS DMC1 DMRTB1 DTX2 DUSP23 DUSP29 DYNLT3 EIF4A3 EIF5A2 ENOX1 EPHB6 FLAD1 FXR2 GNMT GRB2 IP6K3 KCNIP1 KCTD17 KCTD7 KCTD9 KRT15 KXD1 LAMTOR3 LMO2 LMO3 MAGEA11 MAPRE2 MLXIPL NATD1 NEK6 NGB NME1 NME7 NOL3 NUDT14 NUDT21 ORC5 PAFAH1B3 PAICS PCBD1 PNMA1 POLR1C PPIH PRTFDC1 PTPA RABAC1 RAD54B RPIA S100A1 SAT1 SEPTIN1 SNF8 SPG21 SSX2IP STAT3 STK16 SULT1A2 SULT1A3 SULT2A1 SYT17 TCL1A THOC7 TIFA TRAF2 TRIM21 TRIM27 TRIP13 TSC22D4 TXN VIM YES1 YWHAQ ZBED1
Entrez ID		51085	60491
HPRD ID		12033	10424
Ensembl ID		ENSG00000009950	ENSG00000196290
Uniprot IDs		Q9NP71	A0A024R3V5 A0A024R3V7 Q9GZT8
PDB IDs		6MJL 6YGJ
Enriched GO Terms of Interacting Partners?
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