ELOB and SMG1

Data Source:
BioGRID (affinity chromatography technology)

		ELOB	SMG1
Description		elongin B	SMG1 nonsense mediated mRNA decay associated PI3K related kinase
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GO Annotations	Cellular Component	Nucleoplasm Cytosol VCB Complex Cul2-RING Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex Elongin Complex	Nucleus Nucleoplasm Cytoplasm Cytosol TORC1 Complex TORC2 Complex
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Telomeric DNA Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Viral Process Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein-containing Complex Assembly	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay DNA Repair MRNA Export From Nucleus Negative Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Regulation Of Telomere Maintenance TORC1 Signaling Protein Autophosphorylation Phosphatidylinositol Phosphorylation Regulation Of Response To DNA Damage Stimulus
Pathways		Formation of RNA Pol II elongation complex Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Vif-mediated degradation of APOBEC3G RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation Neddylation Regulation of expression of SLITs and ROBOs Antigen processing: Ubiquitination & Proteasome degradation	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS			Health literacy ( 31250787) Heel bone mineral density ( 30598549) Refractive error ( 32231278)
Interacting Genes		21 interacting genes: ASB11 ASB2 ASB8 CEBPE ELOA ELOA2 ELOA3P ELOC EPOR GHR GPS1 LRRC41 MRPL53 PRAME RACK1 RNF7 SOCS1 SOCS3 SOCS6 VHL ZYG11B	9 interacting genes: CDH5 PRKCI SMAD9 SMG5 SMG8 SNAPIN UPF1 UPF2 UPF3A
Entrez ID		6923	23049
HPRD ID		02874	06123
Ensembl ID		ENSG00000103363	ENSG00000157106
Uniprot IDs		A0A384MDL3 Q15370	Q96Q15
PDB IDs		1LM8 1LQB 1VCB 2C9W 2IZV 2JZ3 2MA9 3DCG 3ZKJ 3ZNG 3ZRC 3ZRF 3ZTC 3ZTD 3ZUN 4AJY 4AWJ 4B95 4B9K 4BKS 4BKT 4N9F 4W9C 4W9D 4W9E 4W9F 4W9G 4W9H 4W9I 4W9J 4W9K 4W9L 4WQO 5BO4 5LLI 5N4W 5NVV 5NVW 5NVX 5NVY 5NVZ 5NW0 5NW1 5NW2 5T35 6BVB 6C5X 6FMI 6FMJ 6FMK 6GFX 6GFY 6GFZ 6GMN 6GMQ 6GMR 6GMX 6HAX 6HAY 6HR2 6I4X 6I5J 6I5N 6I7Q 6I7R 6P59 6R6H 6R7F 6R7H 6R7I 6R7N 6SIS 6V9H 6ZHC	6L53 6L54 6SYT 6Z3R
Enriched GO Terms of Interacting Partners?
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