CNTN2 and L1CAM

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		CNTN2	L1CAM
Description		contactin 2	L1 cell adhesion molecule
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Axon Node Of Ranvier Myelin Sheath Juxtaparanode Region Of Axon Synapse Anchored Component Of Postsynaptic Membrane	Plasma Membrane Focal Adhesion Cell Surface Integral Component Of Membrane Axon Dendrite Neuronal Cell Body Axonal Growth Cone Collagen-containing Extracellular Matrix
	Molecular Function	Protein Binding Identical Protein Binding Cell-cell Adhesion Mediator Activity	Protein Binding Axon Guidance Receptor Activity Protein Domain Specific Binding
	Biological Process	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Axon Guidance Clustering Of Voltage-gated Potassium Channels Dendrite Self-avoidance Protein Localization To Juxtaparanode Region Of Axon Presynaptic Membrane Organization	Chemotaxis Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-matrix Adhesion Nervous System Development Axon Guidance Cell Migration Neuron Projection Development Positive Regulation Of Axon Extension Synapse Organization Leukocyte Migration Axon Development
Pathways		L1CAM interactions NCAM1 interactions NrCAM interactions	Basigin interactions L1CAM interactions L1CAM interactions Recycling pathway of L1 Recycling pathway of L1 Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins Signal transduction by L1
Drugs			Ethanol
Diseases			Hereditary spastic paraplegia (SPG) Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS) L1 syndrome, including: ; X-linked hydrocephalus; MASA syndrome; X-linked complicated spastic paraplegia type I ; X-linked partial agenesis of corpus callosum
GWAS		Adventurousness ( 30643258) Blood protein levels ( 30072576 29875488 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) HDL cholesterol levels ( 32203549) Mean platelet volume ( 24026423) Meat-related diet ( 32066663) Number of sexual partners ( 30643258) Red blood cell count ( 27863252) Schizophrenia ( 30285260) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		11 interacting genes: CDK4 CHEK1 CNTN1 CNTNAP2 EGFR L1CAM NCAN NFYB NRCAM TUBG1 VAC14	24 interacting genes: ANK1 ANK2 CNTN1 CNTN2 CSNK2A1 EZR FGFR1 ITGA5 ITGAV LINC00839 MSN NCAM1 NCAN NRP1 NRP2 NUMB PEA15 PLXNA1 PLXNB1 PRNP RANBP9 RDX RPS6KA1 RPS6KA2
Entrez ID		6900	3897
HPRD ID		01826	02394
Ensembl ID		ENSG00000184144	ENSG00000198910
Uniprot IDs		A1L3A3 A1ML24 Q02246	P32004
PDB IDs		2OM5
Enriched GO Terms of Interacting Partners?
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