TAF1 and CDC42BPA

Data Source:
BioGRID (two hybrid)

		TAF1	CDC42BPA
Description		TATA-box binding protein associated factor 1	CDC42 binding protein kinase alpha
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Transcription Factor TFIID Complex Nucleolus MLL1 Complex	Cytoplasm Cytoskeleton Cell-cell Junction Lamellipodium Cell Leading Edge Actomyosin Extracellular Exosome
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase I General Transcription Initiation Factor Activity P53 Binding Histone Acetyltransferase Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Transcription Factor Binding RNA Polymerase II General Transcription Initiation Factor Activity Kinase Activity TBP-class Protein Binding Nuclear Hormone Receptor Binding Sequence-specific DNA Binding Protein Heterodimerization Activity H3K27me3 Modified Histone Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Ubiquitin Conjugating Enzyme Activity Lysine-acetylated Histone Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity Transcription Regulator Inhibitor Activity Acetyl-CoA Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Transcription Initiation From RNA Polymerase I Promoter Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Protein Phosphorylation Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Cell Cycle Negative Regulation Of Gene Expression Viral Process Histone Acetylation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Midbrain Development Positive Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To UV Transcription Factor Catabolic Process Negative Regulation Of DNA-binding Transcription Factor Activity Protein Autophosphorylation Protein Stabilization RNA Polymerase II Preinitiation Complex Assembly Cellular Response To ATP Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Protein Autoubiquitination Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Androgen Receptor Activity	Protein Phosphorylation Cell Migration Peptidyl-threonine Phosphorylation Actomyosin Structure Organization Actin Cytoskeleton Reorganization Intracellular Signal Transduction
Pathways		HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance
Drugs
Diseases
GWAS			Blond vs. brown/black hair color ( 30531825) Blood urea nitrogen levels ( 31152163) Cardiovascular death or myocardial infarction in response to clopidogrel treatment ( 32472697) Diastolic blood pressure ( 28135244) Macular thickness ( 30535121) Mercury levels ( 26025379) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494) Optic cup area ( 25631615 31798171) Optic disc area ( 25631615 31798171 28073927) Optic disc size ( 31809533) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) White blood cell count ( 32888494)
Interacting Genes		57 interacting genes: APC AR ASF1A ASF1B BRMS1 CCNA2 CCND1 CDC42BPA CLIP4 DNAJB5 DOCK9 DYSF EDF1 EWSR1 FOS GFI1B GTF2A1 GTF2E1 GTF2F1 H1-1 H3-4 HMGB1 HSF1 ITGB5 JUN LHX3 MAX MDM2 MSX1 MYOM2 PAX3 PRKD3 RANBP2 RB1 RBL1 RBL2 RELA SGCA SPTAN1 SUB1 SUMO2 TAF10 TAF11 TAF12 TAF15 TAF2 TAF4 TAF4B TAF5 TAF6 TAF7 TAF8 TAF9 TBP TP53 UBE2I UBTF	10 interacting genes: CDC42 CDC42BPB LIMK1 LIMK2 MYL2 MYL9 PPM1A PPP1R12C SNAPIN TAF1
Entrez ID		6872	8476
HPRD ID		02436	04562
Ensembl ID		ENSG00000147133	ENSG00000143776
Uniprot IDs		P21675	Q5VT25
PDB IDs		1EQF 3AAD 3UV4 3UV5 4RGW 4YYM 4YYN 5FUR 5I1Q 5I29 5MG2 6BQD 6FIC 6MZD 6MZL 6MZM 6P38 6P39 6P3A
Enriched GO Terms of Interacting Partners?
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