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TAF1 and H1-1
Data Source:
BioGRID
(enzymatic study)
TAF1
H1-1
Description
TATA-box binding protein associated factor 1
H1.1 linker histone, cluster member
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Transcription Factor TFIID Complex
Nucleolus
MLL1 Complex
Chromatin
Nucleosome
Euchromatin
Nucleus
Nucleoplasm
Molecular Function
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
RNA Polymerase I General Transcription Initiation Factor Activity
P53 Binding
Histone Acetyltransferase Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Transcription Factor Binding
RNA Polymerase II General Transcription Initiation Factor Activity
Kinase Activity
TBP-class Protein Binding
Nuclear Hormone Receptor Binding
Sequence-specific DNA Binding
Protein Heterodimerization Activity
H3K27me3 Modified Histone Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Ubiquitin Conjugating Enzyme Activity
Lysine-acetylated Histone Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Transcription Regulator Inhibitor Activity
Acetyl-CoA Binding
Double-stranded DNA Binding
Protein Binding
Chromatin DNA Binding
Nucleosomal DNA Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Protein Polyubiquitination
Transcription Initiation From RNA Polymerase I Promoter
Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Protein Phosphorylation
Ubiquitin-dependent Protein Catabolic Process
Cellular Response To DNA Damage Stimulus
Cell Cycle
Negative Regulation Of Gene Expression
Viral Process
Histone Acetylation
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Midbrain Development
Positive Regulation Of Protein Binding
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Response To UV
Transcription Factor Catabolic Process
Negative Regulation Of DNA-binding Transcription Factor Activity
Protein Autophosphorylation
Protein Stabilization
RNA Polymerase II Preinitiation Complex Assembly
Cellular Response To ATP
Regulation Of Signal Transduction By P53 Class Mediator
Regulation Of Cell Cycle G1/S Phase Transition
Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
Negative Regulation Of Protein Autoubiquitination
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Androgen Receptor Activity
Nucleosome Assembly
Spermatogenesis
Nucleosome Positioning
Chromosome Condensation
Negative Regulation Of Chromatin Silencing
Negative Regulation Of DNA Recombination
Pathways
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
RNA Polymerase II Pre-transcription Events
Regulation of TP53 Activity through Phosphorylation
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Initiation And Promoter Clearance
Apoptosis induced DNA fragmentation
Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
Diseases
GWAS
Interacting Genes
57 interacting genes:
APC
AR
ASF1A
ASF1B
BRMS1
CCNA2
CCND1
CDC42BPA
CLIP4
DNAJB5
DOCK9
DYSF
EDF1
EWSR1
FOS
GFI1B
GTF2A1
GTF2E1
GTF2F1
H1-1
H3-4
HMGB1
HSF1
ITGB5
JUN
LHX3
MAX
MDM2
MSX1
MYOM2
PAX3
PRKD3
RANBP2
RB1
RBL1
RBL2
RELA
SGCA
SPTAN1
SUB1
SUMO2
TAF10
TAF11
TAF12
TAF15
TAF2
TAF4
TAF4B
TAF5
TAF6
TAF7
TAF8
TAF9
TBP
TP53
UBE2I
UBTF
52 interacting genes:
AEBP2
APP
CCNA1
CCNA2
CCNB1
CCND2
CCNE1
CDK1
CDK2
CDK4
CDK5
CDK6
CDK7
CDKN1B
CRP
CTCFL
EED
EHMT2
EP300
EZH2
GADD45A
GZMA
IRAK4
KAT2B
LIMK1
LIMK2
LOX
NAP1L1
NAP1L4
NASP
NSD3
PAK4
PARP1
PARP3
PELP1
PRDM1
PRKCA
PRKCB
PRKCD
PRKCE
PRKCZ
PRKDC
PTMA
RBBP4
RPS6KA5
SET
SNCA
SUZ12
TAF1
TERF1
TERF2IP
TLK1
Entrez ID
6872
3024
HPRD ID
02436
00820
Ensembl ID
ENSG00000147133
ENSG00000124610
Uniprot IDs
P21675
Q02539
PDB IDs
1EQF
3AAD
3UV4
3UV5
4RGW
4YYM
4YYN
5FUR
5I1Q
5I29
5MG2
6BQD
6FIC
6MZD
6MZL
6MZM
6P38
6P39
6P3A
Enriched GO Terms of Interacting Partners
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