SUPT4H1 and HTATSF1

Data Source:
HPRD (in vivo)

		SUPT4H1	HTATSF1
Description		SPT4 homolog, DSIF elongation factor subunit	HIV-1 Tat specific factor 1
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GO Annotations	Cellular Component	Nucleoplasm DSIF Complex	Nucleus Nucleoplasm U2-type Spliceosomal Complex U2 SnRNP
	Molecular Function	RNA Polymerase II Complex Binding Protein Binding Zinc Ion Binding Protein Heterodimerization Activity	RNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of Transcription, DNA-templated Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter MRNA Processing Negative Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Transcription Elongation From RNA Polymerase II Promoter Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Viral Transcription	MRNA Splicing, Via Spliceosome Regulation Of Transcription By RNA Polymerase II Viral Genome Replication Regulation Of DNA-templated Transcription, Elongation
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Eosinophil percentage of white cells ( 32888494) Mental health study participation (completed survey) ( 31263887) Refractive error ( 32231278)
Interacting Genes		11 interacting genes: ANXA5 APP EWSR1 HTATSF1 LRIF1 LRRK2 MFHAS1 NSG2 PDLIM1 SUPT5H XRCC5	19 interacting genes: APBB1 CCNT1 CDK9 CLK1 CSNK2A1 ERCC6 FEZ1 GTF2F2 HDAC6 POLR2A SF3A2 SNRNP70 SNRPB2 SRPK2 SRSF4 SUPT4H1 SUPT5H WBP4 ZNF512B
Entrez ID		6827	27336
HPRD ID		16026	02282
Ensembl ID		ENSG00000213246	ENSG00000102241
Uniprot IDs		P63272	O43719
PDB IDs		3H7H 5OIK 6GMH 6GML 6TED	2DIT 6N3D 6N3E 6N3F 6NSX 6Y50 6Y53 6Y5Q
Enriched GO Terms of Interacting Partners?
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