HTATSF1 and APBB1

Data Source:
BioGRID (pull down)

		HTATSF1	APBB1
Description		HIV-1 Tat specific factor 1	amyloid beta precursor protein binding family B member 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm U2-type Spliceosomal Complex U2 SnRNP	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Plasma Membrane Nuclear Speck Lamellipodium Growth Cone Synapse
	Molecular Function	RNA Binding	Amyloid-beta Binding Chromatin Binding Transcription Coactivator Activity Protein Binding Transcription Factor Binding Ubiquitin Protein Ligase Binding Histone Binding Low-density Lipoprotein Particle Receptor Binding Proline-rich Region Binding
	Biological Process	MRNA Splicing, Via Spliceosome Regulation Of Transcription By RNA Polymerase II Viral Genome Replication Regulation Of DNA-templated Transcription, Elongation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Apoptotic Process Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Signal Transduction Axonogenesis Negative Regulation Of Cell Growth Positive Regulation Of Apoptotic Process Histone H4 Acetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Secretion
Pathways			Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Drugs
Diseases
GWAS			Blood protein levels ( 29875488) Malaria ( 31844061)
Interacting Genes		19 interacting genes: APBB1 CCNT1 CDK9 CLK1 CSNK2A1 ERCC6 FEZ1 GTF2F2 HDAC6 POLR2A SF3A2 SNRNP70 SNRPB2 SRPK2 SRSF4 SUPT4H1 SUPT5H WBP4 ZNF512B	69 interacting genes: ABI1 ABL1 ANXA1 APLP1 APLP2 APP ARF6 ATXN1 ATXN1L CCDC97 CHERP CLSTN1 CPSF6 CPSF7 CYFIP1 CYFIP2 DDX17 DDX3X DDX46 DHX15 DHX9 DIAPH1 DIAPH2 EGFR ELMO1 ENAH ERBB2 EVL FASLG HNRNPH1 HNRNPK HTATSF1 KAT5 KHDRBS1 KHSRP LRP1 LRP2 NONO PABPC1 PQBP1 PRNP PTBP1 RBM17 RPL4 SF1 SF3A1 SF3A2 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ TENM1 TFCP2 THRAP3 TSHZ1 TSHZ2 TSHZ3 U2AF2 VASP WAS WASF2 WASL WBP11 WIPF1 WIPF2 YBX1 YLPM1
Entrez ID		27336	322
HPRD ID		02282	04087
Ensembl ID		ENSG00000102241	ENSG00000166313
Uniprot IDs		O43719	B7Z4M9 O00213
PDB IDs		2DIT 6N3D 6N3E 6N3F 6NSX 6Y50 6Y53 6Y5Q	2E45 2HO2 2IDH 2OEI 3D8D 3D8E 3D8F 3DXC 3DXD 3DXE 5NQH
Enriched GO Terms of Interacting Partners?
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