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AURKC and OTX2
Data Source:
BioGRID
(two hybrid)
AURKC
OTX2
Description
aurora kinase C
orthodenticle homeobox 2
Image
No pdb structure
GO Annotations
Cellular Component
Condensed Chromosome
Nucleus
Cytoplasm
Spindle
Spindle Microtubule
Midbody
Spindle Pole Centrosome
Chromosome Passenger Complex
Spindle Midzone
Chromatin
Nucleus
Growth Cone
Protein-containing Complex
Molecular Function
Protein Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Binding
ATP Binding
Histone Serine Kinase Activity
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Protein Binding
Eukaryotic Initiation Factor 4E Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Protein Phosphorylation
Mitotic Spindle Organization
Spermatogenesis
Attachment Of Spindle Microtubules To Kinetochore
Histone Modification
Regulation Of Cytokinesis
Positive Regulation Of Cytokinesis
Histone-serine Phosphorylation
Oocyte Development
Mitotic Spindle Midzone Assembly
Cell Division
Meiotic Cell Cycle
Regulation Of Transcription By RNA Polymerase II
Axon Guidance
Regulation Of Smoothened Signaling Pathway
Forebrain Development
Midbrain Development
Positive Regulation Of Embryonic Development
Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Protein-containing Complex Assembly
Dopaminergic Neuron Differentiation
Primitive Streak Formation
Positive Regulation Of Gastrulation
Pathways
Drugs
SNS-314
Fostamatinib
Diseases
Anophthalmia and microphthalmia (A/M)
Septo-optic dysplasia
GWAS
Alcohol consumption (
31358974
)
Alcohol consumption (drinks per week) (
30643258
)
Chronotype (
30696823
)
Moderate-to-late spontaneous preterm birth (
31194736
)
Refractive error (
32231278
)
Interacting Genes
13 interacting genes:
BIRC5
BIRC7
BRCA1
CADPS
CENPA
H3C1
INCENP
LNX1
NEDD4
NEDD4L
OTX2
SRPK1
TACC2
43 interacting genes:
APP
ASIC4
ATP6V1G3
ATXN1
AURKC
B4GALNT2
BNIP2
CDK3
CDK4
DMBX1
FOXA2
GPR45
GUCA1B
HIKESHI
HNF1B
HOMER3
HSD3B7
IQGAP1
JPT1
KLF3
LHX1
M1AP
MITF
NAA50
OR1L3
OR6C1
POLDIP3
RBM47
RNASE11
RPS26
RTCA
SMARCB1
SNRPA
TBCEL
TENT5B
TLE4
TMEM11
TNPO2
TRMT10B
ZC3H10
ZDHHC17
ZNF765
ZNHIT1
Entrez ID
6795
5015
HPRD ID
04605
07190
Ensembl ID
ENSG00000105146
ENSG00000165588
Uniprot IDs
Q9UQB9
F1T0C9
F1T0D0
F1T0D1
P32243
PDB IDs
6GR8
6GR9
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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