AURKC and INCENP

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		AURKC	INCENP
Description		aurora kinase C	inner centromere protein
Image
GO Annotations	Cellular Component	Condensed Chromosome Nucleus Cytoplasm Spindle Spindle Microtubule Midbody Spindle Pole Centrosome Chromosome Passenger Complex Spindle Midzone	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Condensed Chromosome Lateral Element Central Element Nucleus Nucleoplasm Pericentric Heterochromatin Spindle Cytosol Microtubule Chromocenter Nuclear Body Midbody Chromosome Passenger Complex Protein-containing Complex Meiotic Spindle Midzone
	Molecular Function	Protein Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Histone Serine Kinase Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Binding Protein Serine/threonine Kinase Activator Activity
	Biological Process	Protein Phosphorylation Mitotic Spindle Organization Spermatogenesis Attachment Of Spindle Microtubules To Kinetochore Histone Modification Regulation Of Cytokinesis Positive Regulation Of Cytokinesis Histone-serine Phosphorylation Oocyte Development Mitotic Spindle Midzone Assembly Cell Division Meiotic Cell Cycle	Mitotic Sister Chromatid Segregation Mitotic Cytokinesis Chromosome Segregation Meiotic Chromosome Condensation Histone Phosphorylation Meiotic Spindle Midzone Assembly Metaphase Plate Congression Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Mitotic Cytokinesis
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA replication proteins RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs		SNS-314 Fostamatinib	Reversine
Diseases
GWAS			Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Prostate cancer ( 29892016) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		13 interacting genes: BIRC5 BIRC7 BRCA1 CADPS CENPA H3C1 INCENP LNX1 NEDD4 NEDD4L OTX2 SRPK1 TACC2	10 interacting genes: AURKA AURKB AURKC BIRC5 CBX5 CDCA8 EVI5 FLOT1 H2AZ1 H3C14
Entrez ID		6795	3619
HPRD ID		04605	05103
Ensembl ID		ENSG00000105146	ENSG00000149503
Uniprot IDs		Q9UQB9	Q9NQS7
PDB IDs		6GR8 6GR9	2QFA 4AF3 5IEH 5IEK 6GR8 6GR9 6YIE 6YIF 6YIH
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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